GO Annotations Graph

• Symbol: Pemt
• Name: phosphatidylethanolamine N-methyltransferase
• ID: MGI:104535

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008168	methyltransferase activity	IEA	J:60000
Molecular Function	GO:0080101	phosphatidyl-N-dimethylethanolamine N-methyltransferase activity	IEA	J:72245
Molecular Function	GO:0000773	phosphatidyl-N-methylethanolamine N-methyltransferase activity	IEA	J:72245
Molecular Function	GO:0008429	phosphatidylethanolamine binding	ISO	J:155856
Molecular Function	GO:0004608	phosphatidylethanolamine N-methyltransferase activity	ISO	J:155856
Molecular Function	GO:0004608	phosphatidylethanolamine N-methyltransferase activity	IBA	J:265628
Molecular Function	GO:0004608	phosphatidylethanolamine N-methyltransferase activity	ISS	J:37266
Molecular Function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	ISO	J:155856
Molecular Function	GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	IMP	J:228568
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0031526	brush border membrane	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0005789	endoplasmic reticulum membrane	IDA	J:78774
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005740	mitochondrial envelope	TAS	J:37266
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0042383	sarcolemma	ISO	J:155856
Biological Process	GO:0001835	blastocyst hatching	IMP	J:244597
Biological Process	GO:0006650	glycerophospholipid metabolic process	ISO	J:155856
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0032259	methylation	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	ISO	J:155856
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	IBA	J:265628
Biological Process	GO:0006656	phosphatidylcholine biosynthetic process	ISS	J:37266
Biological Process	GO:0008654	phospholipid biosynthetic process	IEA	J:60000
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:225725
Biological Process	GO:0050747	positive regulation of lipoprotein metabolic process	ISO	J:155856
Biological Process	GO:0033273	response to vitamin	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0046498	S-adenosylhomocysteine metabolic process	ISO	J:155856
Biological Process	GO:0046500	S-adenosylmethionine metabolic process	ISO	J:155856
Biological Process	GO:0006686	sphingomyelin biosynthetic process	IMP	J:228568