GO Annotations Graph

• Symbol: Brca1
• Name: breast cancer 1, early onset
• ID: MGI:104537

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003684	damaged DNA binding	IDA	J:76360
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	ISO	J:79872
Molecular Function	GO:0070063	RNA polymerase binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	IDA	J:173146
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0070531	BRCA1-A complex	ISO	J:164563
Cellular Component	GO:0070531	BRCA1-A complex	NAS	J:320081
Cellular Component	GO:0070531	BRCA1-A complex	IBA	J:265628
Cellular Component	GO:0070532	BRCA1-B complex	ISO	J:164563
Cellular Component	GO:0031436	BRCA1-BARD1 complex	ISO	J:164563
Cellular Component	GO:0031436	BRCA1-BARD1 complex	IBA	J:265628
Cellular Component	GO:0070533	BRCA1-C complex	ISO	J:164563
Cellular Component	GO:0005813	centrosome	TAS	J:113897
Cellular Component	GO:0005694	chromosome	IDA	J:192634
Cellular Component	GO:0005694	chromosome	IDA	J:183982
Cellular Component	GO:0000793	condensed chromosome	IDA	J:85108
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:161203
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:227337
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:74101
Cellular Component	GO:1990391	DNA repair complex	ISO	J:164563
Cellular Component	GO:0043232	intracellular non-membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0000800	lateral element	ISO	J:113839
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:284005
Cellular Component	GO:0005759	mitochondrial matrix	ISO	J:155856
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0000152	nuclear ubiquitin ligase complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912421
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912423
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912431
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912449
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912468
Cellular Component	GO:0005634	nucleus	NAS	J:319979
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	NAS	J:320080
Cellular Component	GO:0005634	nucleus	NAS	J:320081
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:113389
Cellular Component	GO:1990904	ribonucleoprotein complex	ISO	J:142821
Cellular Component	GO:0001741	XY body	IDA	J:284005
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071681	cellular response to indole-3-methanol	ISO	J:164563
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:0071356	cellular response to tumor necrosis factor	ISO	J:164563
Biological Process	GO:0007098	centrosome cycle	IGI	J:91673
Biological Process	GO:0051298	centrosome duplication	TAS	J:113897
Biological Process	GO:0043009	chordate embryonic development	IBA	J:265628
Biological Process	GO:0043009	chordate embryonic development	IMP	J:40594
Biological Process	GO:0007059	chromosome segregation	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	NAS	J:319986
Biological Process	GO:0006974	DNA damage response	IMP	J:192592
Biological Process	GO:0006310	DNA recombination	IEA	J:60000
Biological Process	GO:0006281	DNA repair	NAS	J:320080
Biological Process	GO:0110025	DNA strand resection involved in replication fork processing	NAS	J:320083
Biological Process	GO:0009048	dosage compensation by inactivation of X chromosome	IBA	J:265628
Biological Process	GO:0009048	dosage compensation by inactivation of X chromosome	IDA	J:79872
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IMP	J:205643
Biological Process	GO:0000724	double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IBA	J:265628
Biological Process	GO:0006633	fatty acid biosynthetic process	IEA	J:60000
Biological Process	GO:0006631	fatty acid metabolic process	IEA	J:60000
Biological Process	GO:0070537	histone H2A K63-linked deubiquitination	NAS	J:320081
Biological Process	GO:0035518	histone H2A monoubiquitination	NAS	J:320082
Biological Process	GO:0035825	homologous recombination	NAS	J:319683
Biological Process	GO:0035825	homologous recombination	NAS	J:320080
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:87001
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	NAS	J:320080
Biological Process	GO:0044818	mitotic G2/M transition checkpoint	IMP	J:92253
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	ISO	J:164563
Biological Process	GO:0045717	negative regulation of fatty acid biosynthetic process	IBA	J:265628
Biological Process	GO:0035067	negative regulation of histone acetylation	IMP	J:173146
Biological Process	GO:0035067	negative regulation of histone acetylation	IBA	J:265628
Biological Process	GO:0051572	negative regulation of histone H3-K4 methylation	IMP	J:173146
Biological Process	GO:0051573	negative regulation of histone H3-K9 methylation	ISO	J:164563
Biological Process	GO:0051573	negative regulation of histone H3-K9 methylation	IMP	J:173146
Biological Process	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	ISO	J:164563
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0045787	positive regulation of cell cycle	NAS	J:319994
Biological Process	GO:0045739	positive regulation of DNA repair	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0035066	positive regulation of histone acetylation	IMP	J:173146
Biological Process	GO:0035066	positive regulation of histone acetylation	ISO	J:164563
Biological Process	GO:0035066	positive regulation of histone acetylation	IBA	J:265628
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	ISO	J:164563
Biological Process	GO:0051571	positive regulation of histone H3-K4 methylation	IMP	J:173146
Biological Process	GO:2000617	positive regulation of histone H3-K9 acetylation	IMP	J:173146
Biological Process	GO:2000617	positive regulation of histone H3-K9 acetylation	ISO	J:164563
Biological Process	GO:0051574	positive regulation of histone H3-K9 methylation	IMP	J:173146
Biological Process	GO:2000620	positive regulation of histone H4-K16 acetylation	ISO	J:164563
Biological Process	GO:2000620	positive regulation of histone H4-K16 acetylation	IMP	J:173146
Biological Process	GO:0070512	positive regulation of histone H4-K20 methylation	IMP	J:173146
Biological Process	GO:0070512	positive regulation of histone H4-K20 methylation	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:155856
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:173146
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0006301	postreplication repair	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0051865	protein autoubiquitination	NAS	J:320082
Biological Process	GO:0085020	protein K6-linked ubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0016567	protein ubiquitination	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:2000001	regulation of DNA damage checkpoint	NAS	J:320084
Biological Process	GO:0044030	regulation of DNA methylation	IMP	J:173146
Biological Process	GO:0006282	regulation of DNA repair	NAS	J:320081
Biological Process	GO:0006349	regulation of gene expression by genomic imprinting	IMP	J:173146
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0043627	response to estrogen	ISO	J:164563
Biological Process	GO:0010212	response to ionizing radiation	ISO	J:164563