GO Annotations Graph

• Symbol: Cdkn1a
• Name: cyclin dependent kinase inhibitor 1A
• ID: MGI:104556

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030332	cyclin binding	IDA	J:211957
Molecular Function	GO:0030332	cyclin binding	IDA	J:78410
Molecular Function	GO:0019912	cyclin-dependent protein kinase activating kinase activity	ISO	J:164563
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:77997
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:217430
Molecular Function	GO:0005515	protein binding	IPI	J:211957
Molecular Function	GO:0005515	protein binding	IPI	J:117431
Molecular Function	GO:0005515	protein binding	IPI	J:248211
Molecular Function	GO:0005515	protein binding	IPI	J:82317
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0005515	protein binding	IPI	J:82317
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004860	protein kinase inhibitor activity	IBA	J:265628
Molecular Function	GO:0140311	protein sequestering activity	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IBA	J:265628
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:68671
Cellular Component	GO:0005829	cytosol	IDA	J:99181
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:188596
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:188596
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:68671
Cellular Component	GO:0005634	nucleus	IDA	J:85809
Cellular Component	GO:0070557	PCNA-p21 complex	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:188596
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0034198	cellular response to amino acid starvation	IMP	J:227362
Biological Process	GO:0034198	cellular response to amino acid starvation	ISO	J:164563
Biological Process	GO:0031668	cellular response to extracellular stimulus	ISO	J:164563
Biological Process	GO:0071480	cellular response to gamma radiation	IDA	J:60946
Biological Process	GO:0071479	cellular response to ionizing radiation	ISO	J:164563
Biological Process	GO:0071493	cellular response to UV-B	IDA	J:217430
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	IGI	J:72780
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IBA	J:265628
Biological Process	GO:0006974	DNA damage response	IMP	J:85569
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO	J:164563
Biological Process	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA	J:60946
Biological Process	GO:0008544	epidermis development	IGI	J:72780
Biological Process	GO:0007507	heart development	IMP	J:211957
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	J:85569
Biological Process	GO:0030216	keratinocyte differentiation	IGI	J:72780
Biological Process	GO:0043616	keratinocyte proliferation	IGI	J:72780
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:1905179	negative regulation of cardiac muscle tissue regeneration	IMP	J:211957
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:88362
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:84930
Biological Process	GO:1904030	negative regulation of cyclin-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:77997
Biological Process	GO:2000279	negative regulation of DNA biosynthetic process	ISO	J:164563
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	ISO	J:73065
Biological Process	GO:0010629	negative regulation of gene expression	IMP	J:105978
Biological Process	GO:0042326	negative regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0032091	negative regulation of protein binding	ISO	J:164563
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0090402	oncogene-induced cell senescence	IMP	J:72780
Biological Process	GO:0090402	oncogene-induced cell senescence	IGI	J:72780
Biological Process	GO:0030890	positive regulation of B cell proliferation	IGI	J:85809
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:164563
Biological Process	GO:0043068	positive regulation of programmed cell death	IMP	J:84930
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:188596
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0006606	protein import into nucleus	IMP	J:105978
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:211957
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:227362
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:82317
Biological Process	GO:1902806	regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IMP	J:105978
Biological Process	GO:2000278	regulation of DNA biosynthetic process	IMP	J:105978
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0007346	regulation of mitotic cell cycle	IDA	J:123623
Biological Process	GO:0007346	regulation of mitotic cell cycle	IMP	J:105978
Biological Process	GO:0007346	regulation of mitotic cell cycle	IDA	J:97648
Biological Process	GO:0009411	response to UV	IMP	J:85569
Biological Process	GO:0072331	signal transduction by p53 class mediator	IEA	J:72247
Biological Process	GO:0042246	tissue regeneration	IMP	J:158653
Biological Process	GO:0042060	wound healing	IMP	J:158653