GO Annotations Graph

• Symbol: Cdkn1b
• Name: cyclin dependent kinase inhibitor 1B
• ID: MGI:104565

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	IDA	J:211957
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA	J:265628
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:19218
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:77997
Molecular Function	GO:0030544	Hsp70 protein binding	ISO	J:155856
Molecular Function	GO:0060090	molecular adaptor activity	ISO	J:164563
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:211957
Molecular Function	GO:0005515	protein binding	IPI	J:200302
Molecular Function	GO:0005515	protein binding	IPI	J:162977
Molecular Function	GO:0005515	protein binding	IPI	J:147145
Molecular Function	GO:0005515	protein binding	IPI	J:28743
Molecular Function	GO:0005515	protein binding	IPI	J:105045
Molecular Function	GO:0005515	protein binding	IPI	J:96084
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:63241
Molecular Function	GO:0005515	protein binding	IPI	J:132869
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0004860	protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0019903	protein phosphatase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	IBA	J:265628
Molecular Function	GO:1990757	ubiquitin ligase activator activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:238763
Cellular Component	GO:0005737	cytoplasm	IDA	J:171468
Cellular Component	GO:0005737	cytoplasm	IDA	J:96084
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-5671980
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-NUL-9618292
Cellular Component	GO:0005829	cytosol	IDA	J:99181
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:238763
Cellular Component	GO:0005634	nucleus	IDA	J:218237
Cellular Component	GO:0005634	nucleus	IDA	J:157099
Cellular Component	GO:0005634	nucleus	IDA	J:102494
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0005634	nucleus	IDA	J:96084
Cellular Component	GO:0005634	nucleus	IDA	J:142037
Cellular Component	GO:0005634	nucleus	IDA	J:62413
Cellular Component	GO:0032991	protein-containing complex	ISO	J:155856
Biological Process	GO:0006915	apoptotic process	IMP	J:115443
Biological Process	GO:0006915	apoptotic process	IMP	J:115443
Biological Process	GO:0048102	autophagic cell death	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0008219	cell death	ISO	J:155856
Biological Process	GO:0071236	cellular response to antibiotic	IDA	J:142037
Biological Process	GO:0071285	cellular response to lithium ion	ISO	J:142037
Biological Process	GO:0071407	cellular response to organic cyclic compound	IDA	J:142037
Biological Process	GO:1904019	epithelial cell apoptotic process	IMP	J:115443
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	IMP	J:115443
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	IMP	J:115443
Biological Process	GO:0060767	epithelial cell proliferation involved in prostate gland development	IMP	J:115443
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IDA	J:28743
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0007507	heart development	IMP	J:211957
Biological Process	GO:0048839	inner ear development	IMP	J:53290
Biological Process	GO:0051179	localization	ISO	J:164563
Biological Process	GO:1905179	negative regulation of cardiac muscle tissue regeneration	IMP	J:211957
Biological Process	GO:1902807	negative regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:73449
Biological Process	GO:1904030	negative regulation of cyclin-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:77997
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:1904036	negative regulation of epithelial cell apoptotic process	IMP	J:115443
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:53290
Biological Process	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	IMP	J:115443
Biological Process	GO:0033673	negative regulation of kinase activity	ISO	J:164563
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0042326	negative regulation of phosphorylation	ISO	J:164563
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1904706	negative regulation of vascular associated smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:218237
Biological Process	GO:0051168	nuclear export	ISO	J:164563
Biological Process	GO:0001890	placenta development	IGI	J:50769
Biological Process	GO:0010942	positive regulation of cell death	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:84930
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Biological Process	GO:0031116	positive regulation of microtubule polymerization	IGI	J:96084
Biological Process	GO:0006813	potassium ion transport	IGI	J:116872
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IMP	J:211957
Biological Process	GO:1902806	regulation of cell cycle G1/S phase transition	ISO	J:164563
Biological Process	GO:0030334	regulation of cell migration	IDA	J:96084
Biological Process	GO:0042127	regulation of cell population proliferation	IEA	J:72247
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0007096	regulation of exit from mitosis	IGI	J:50769
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:1902746	regulation of lens fiber cell differentiation	IGI	J:50769
Biological Process	GO:0007346	regulation of mitotic cell cycle	IDA	J:19218
Biological Process	GO:0007605	sensory perception of sound	IMP	J:53290