GO Annotations Graph

• Symbol: Hcls1
• Name: hematopoietic cell specific Lyn substrate 1
• ID: MGI:104568

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IEA	J:72247
Molecular Function	GO:0051015	actin filament binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:116375
Molecular Function	GO:0005515	protein binding	IPI	J:116375
Molecular Function	GO:0005515	protein binding	IPI	J:16376
Molecular Function	GO:0005515	protein binding	IPI	J:64960
Molecular Function	GO:0005515	protein binding	IPI	J:148303
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:148303
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:148303
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	IDA	J:51726
Molecular Function	GO:0017124	SH3 domain binding	IPI	J:148303
Cellular Component	GO:0005884	actin filament	IBA	J:265628
Cellular Component	GO:0030864	cortical actin cytoskeleton	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:116375
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IDA	J:116375
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0030427	site of polarized growth	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Biological Process	GO:0030041	actin filament polymerization	IEA	J:72247
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0030218	erythrocyte differentiation	IMP	J:116375
Biological Process	GO:2000107	negative regulation of leukocyte apoptotic process	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:190337
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:116375
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	ISO	J:164563
Biological Process	GO:0030854	positive regulation of granulocyte differentiation	IMP	J:190337
Biological Process	GO:0045651	positive regulation of macrophage differentiation	IMP	J:190337
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0042307	positive regulation of protein import into nucleus	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:190337
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:116375
Biological Process	GO:0030833	regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0030833	regulation of actin filament polymerization	IBA	J:265628
Biological Process	GO:0009725	response to hormone	IDA	J:116375