GO Annotations Graph

• Symbol: Sh3bp1
• Name: SH3-domain binding protein 1
• ID: MGI:104603

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005096	GTPase activator activity	IDA	J:26883
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:155856
Molecular Function	GO:0005096	GTPase activator activity	IBA	J:265628
Molecular Function	GO:0030215	semaphorin receptor binding	ISO	J:164563
Molecular Function	GO:0017124	SH3 domain binding	IPI	J:57558
Cellular Component	GO:0005912	adherens junction	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	IDA	J:263239
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0031252	cell leading edge	ISO	J:164563
Cellular Component	GO:0031252	cell leading edge	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:72247
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0000145	exocyst	ISO	J:164563
Cellular Component	GO:0005622	intracellular anatomical structure	IBA	J:265628
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0001891	phagocytic cup	ISO	J:164563
Biological Process	GO:0007015	actin filament organization	ISO	J:164563
Biological Process	GO:0034329	cell junction assembly	ISO	J:164563
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	ISO	J:164563
Biological Process	GO:0046847	filopodium assembly	ISO	J:155856
Biological Process	GO:0051058	negative regulation of small GTPase mediated signal transduction	ISO	J:164563
Biological Process	GO:0006909	phagocytosis	IEA	J:60000
Biological Process	GO:0006911	phagocytosis, engulfment	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:155856
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IDA	J:26883
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0030834	regulation of actin filament depolymerization	ISO	J:164563
Biological Process	GO:0043535	regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0035020	regulation of Rac protein signal transduction	IBA	J:265628
Biological Process	GO:0097178	ruffle assembly	IMP	J:26883
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:72247