GO Annotations Graph

• Symbol: Ccr1
• Name: C-C motif chemokine receptor 1
• ID: MGI:104618

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019957	C-C chemokine binding	ISO	J:164563
Molecular Function	GO:0019957	C-C chemokine binding	ISO	J:155856
Molecular Function	GO:0016493	C-C chemokine receptor activity	ISO	J:164563
Molecular Function	GO:0016493	C-C chemokine receptor activity	IDA	J:29873
Molecular Function	GO:0071791	chemokine (C-C motif) ligand 5 binding	ISO	J:164563
Molecular Function	GO:0071791	chemokine (C-C motif) ligand 5 binding	IBA	J:265628
Molecular Function	GO:0035717	chemokine (C-C motif) ligand 7 binding	ISO	J:164563
Molecular Function	GO:0035717	chemokine (C-C motif) ligand 7 binding	IBA	J:265628
Molecular Function	GO:0004950	chemokine receptor activity	ISO	J:164563
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004435	phosphatidylinositol phospholipase C activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:29873
Molecular Function	GO:0005515	protein binding	IPI	J:32263
Molecular Function	GO:0005515	protein binding	IPI	J:29873
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0007267	cell-cell signaling	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	IEA	J:72247
Biological Process	GO:0006887	exocytosis	ISO	J:164563
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0006954	inflammatory response	IMP	J:41324
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0030595	leukocyte chemotaxis	IMP	J:41324
Biological Process	GO:0030595	leukocyte chemotaxis	IDA	J:29873
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:41324
Biological Process	GO:0030502	negative regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:169909
Biological Process	GO:0051928	positive regulation of calcium ion transport	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0090026	positive regulation of monocyte chemotaxis	ISO	J:164563
Biological Process	GO:0045672	positive regulation of osteoclast differentiation	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000