GO Annotations Graph

• Symbol: Penk
• Name: preproenkephalin
• ID: MGI:104629

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0001515	opioid peptide activity	IDA	J:322689
Molecular Function	GO:0001515	opioid peptide activity	IDA	J:322698
Molecular Function	GO:0031628	opioid receptor binding	IDA	J:322698
Molecular Function	GO:0031628	opioid receptor binding	IDA	J:322689
Molecular Function	GO:0031628	opioid receptor binding	IBA	J:265628
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	IBA	J:265628
Cellular Component	GO:0070852	cell body fiber	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IBA	J:265628
Cellular Component	GO:0099013	neuronal dense core vesicle lumen	ISO	J:155856
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0032280	symmetric synapse	ISO	J:155856
Cellular Component	GO:0034592	synaptic vesicle lumen	ISO	J:155856
Biological Process	GO:0002118	aggressive behavior	IMP	J:35826
Biological Process	GO:0001662	behavioral fear response	IMP	J:67551
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0007626	locomotory behavior	IMP	J:35826
Biological Process	GO:0035641	locomotory exploration behavior	ISO	J:155856
Biological Process	GO:0007218	neuropeptide signaling pathway	IBA	J:265628
Biological Process	GO:2000987	positive regulation of behavioral fear response	ISO	J:155856
Biological Process	GO:1900452	regulation of long-term synaptic depression	IDA	J:322689
Biological Process	GO:0009617	response to bacterium	IEP	J:190322
Biological Process	GO:0007600	sensory perception	IBA	J:265628
Biological Process	GO:0019233	sensory perception of pain	IMP	J:35826
Biological Process	GO:0001964	startle response	IMP	J:35826
Biological Process	GO:0099538	synaptic signaling via neuropeptide	ISO	J:155856