GO Annotations Graph

• Symbol: Tgfbr3
• Name: transforming growth factor, beta receptor III
• ID: MGI:104637

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:155856
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0017134	fibroblast growth factor binding	ISO	J:155856
Molecular Function	GO:0005539	glycosaminoglycan binding	IDA	J:83727
Molecular Function	GO:0008201	heparin binding	ISO	J:155856
Molecular Function	GO:0030165	PDZ domain binding	IPI	J:139342
Molecular Function	GO:0005515	protein binding	IPI	J:83727
Molecular Function	GO:0046332	SMAD binding	IMP	J:118378
Molecular Function	GO:0046332	SMAD binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	IDA	J:118378
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:155856
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:155856
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0050431	transforming growth factor beta binding	ISO	J:164563
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	ISO	J:164563
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IDA	J:48601
Molecular Function	GO:0005024	transforming growth factor beta receptor activity	IMP	J:126837
Molecular Function	GO:0070123	transforming growth factor beta receptor activity, type III	ISO	J:155856
Molecular Function	GO:0070123	transforming growth factor beta receptor activity, type III	ISO	J:164563
Molecular Function	GO:0005160	transforming growth factor beta receptor binding	ISO	J:155856
Molecular Function	GO:0005114	type II transforming growth factor beta receptor binding	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:139342
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:134998
Cellular Component	GO:0005737	cytoplasm	IDA	J:51778
Cellular Component	GO:0005783	endoplasmic reticulum	IDA	J:51778
Cellular Component	GO:0009897	external side of plasma membrane	ISO	J:164563
Cellular Component	GO:0031012	extracellular matrix	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0034673	inhibin-betaglycan-ActRII complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	J:169941
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:155856
Biological Process	GO:0060561	apoptotic process involved in morphogenesis	IMP	J:218259
Biological Process	GO:0001824	blastocyst development	IDA	J:51778
Biological Process	GO:0001568	blood vessel development	IMP	J:141344
Biological Process	GO:0097746	blood vessel diameter maintenance	TAS	J:169941
Biological Process	GO:0001974	blood vessel remodeling	IMP	J:218259
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:218259
Biological Process	GO:0060317	cardiac epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:83727
Biological Process	GO:0008283	cell population proliferation	IMP	J:218259
Biological Process	GO:0032963	collagen metabolic process	IGI	J:224728
Biological Process	GO:0060976	coronary vasculature development	TAS	J:169941
Biological Process	GO:0060977	coronary vasculature morphogenesis	TAS	J:169941
Biological Process	GO:0060318	definitive erythrocyte differentiation	IMP	J:83727
Biological Process	GO:0060216	definitive hemopoiesis	IMP	J:83727
Biological Process	GO:0003347	epicardial cell to mesenchymal cell transition	TAS	J:169941
Biological Process	GO:0060939	epicardium-derived cardiac fibroblast cell development	IMP	J:141344
Biological Process	GO:0001837	epithelial to mesenchymal transition	ISO	J:164563
Biological Process	GO:0060347	heart trabecula formation	IMP	J:83727
Biological Process	GO:0061384	heart trabecula morphogenesis	IMP	J:83727
Biological Process	GO:0006955	immune response	ISO	J:164563
Biological Process	GO:0001701	in utero embryonic development	IMP	J:141344
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0001889	liver development	IMP	J:83727
Biological Process	GO:0003150	muscular septum morphogenesis	IMP	J:83727
Biological Process	GO:1902338	negative regulation of apoptotic process involved in morphogenesis	IMP	J:218259
Biological Process	GO:0010633	negative regulation of epithelial cell migration	IMP	J:126837
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:118378
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	IMP	J:126837
Biological Process	GO:0010629	negative regulation of gene expression	IDA	J:224728
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:218259
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:141344
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0060389	pathway-restricted SMAD protein phosphorylation	IMP	J:118378
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IMP	J:218259
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:83727
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:218259
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IMP	J:126837
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	IMP	J:218259
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0043393	regulation of protein binding	ISO	J:155856
Biological Process	GO:0032354	response to follicle-stimulating hormone	ISO	J:164563
Biological Process	GO:0034699	response to luteinizing hormone	ISO	J:164563
Biological Process	GO:0034695	response to prostaglandin E	ISO	J:164563
Biological Process	GO:0060021	roof of mouth development	IMP	J:218259
Biological Process	GO:0062009	secondary palate development	IMP	J:118378
Biological Process	GO:0007181	transforming growth factor beta receptor complex assembly	ISO	J:155856
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IGI	J:83727
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:118378
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IDA	J:139342
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:218259
Biological Process	GO:0001570	vasculogenesis	IMP	J:218259
Biological Process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	TAS	J:169941
Biological Process	GO:0060979	vasculogenesis involved in coronary vascular morphogenesis	IMP	J:141344
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	IMP	J:83727
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	IMP	J:141344
Biological Process	GO:0003223	ventricular compact myocardium morphogenesis	IMP	J:83727
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:141344
Biological Process	GO:0061032	visceral serous pericardium development	TAS	J:169941