GO Annotations Graph

• Symbol: Dll1
• Name: delta like canonical Notch ligand 1
• ID: MGI:104659

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005112	Notch binding	ISO	J:155856
Molecular Function	GO:0005112	Notch binding	IPI	J:180704
Molecular Function	GO:0005112	Notch binding	IPI	J:224738
Molecular Function	GO:0005112	Notch binding	ISO	J:164563
Molecular Function	GO:0005112	Notch binding	IPI	J:88030
Molecular Function	GO:0005112	Notch binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:88030
Molecular Function	GO:0005515	protein binding	IPI	J:245710
Molecular Function	GO:0005515	protein binding	IPI	J:173235
Molecular Function	GO:0005515	protein binding	IPI	J:227382
Molecular Function	GO:0005515	protein binding	IPI	J:225411
Molecular Function	GO:0005515	protein binding	IPI	J:180704
Molecular Function	GO:0005515	protein binding	IPI	J:208850
Molecular Function	GO:0005515	protein binding	IPI	J:117595
Molecular Function	GO:0005515	protein binding	IPI	J:114126
Molecular Function	GO:0005515	protein binding	IPI	J:84628
Molecular Function	GO:0005515	protein binding	IPI	J:101173
Molecular Function	GO:0005515	protein binding	IPI	J:97329
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:164563
Molecular Function	GO:0097110	scaffold protein binding	IPI	J:100814
Molecular Function	GO:0030957	Tat protein binding	ISO	J:164563
Cellular Component	GO:0005912	adherens junction	IDA	J:100814
Cellular Component	GO:0005912	adherens junction	IDA	J:208850
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:208850
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:101173
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	IDA	J:224738
Cellular Component	GO:0045121	membrane raft	IDA	J:180704
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2060798
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2193065
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9012873
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9023350
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9793915
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	IDA	J:101173
Biological Process	GO:0009887	animal organ morphogenesis	NAS	J:56816
Biological Process	GO:0014002	astrocyte development	IMP	J:199717
Biological Process	GO:0009912	auditory receptor cell fate commitment	NAS	J:60836
Biological Process	GO:0009912	auditory receptor cell fate commitment	NAS	J:56415
Biological Process	GO:0007154	cell communication	IEA	J:72247
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0007267	cell-cell signaling	IDA	J:131628
Biological Process	GO:0021688	cerebellar molecular layer formation	IMP	J:199717
Biological Process	GO:0021693	cerebellar Purkinje cell layer structural organization	IMP	J:199717
Biological Process	GO:0072583	clathrin-dependent endocytosis	ISO	J:155856
Biological Process	GO:0007386	compartment pattern specification	IMP	J:77247
Biological Process	GO:0007368	determination of left/right symmetry	IMP	J:83358
Biological Process	GO:0097102	endothelial tip cell fate specification	IMP	J:192694
Biological Process	GO:0097009	energy homeostasis	IMP	J:150183
Biological Process	GO:0001947	heart looping	IMP	J:83358
Biological Process	GO:0042386	hemocyte differentiation	IDA	J:131628
Biological Process	GO:0001701	in utero embryonic development	NAS	J:56816
Biological Process	GO:0002085	inhibition of neuroepithelial cell differentiation	IMP	J:107414
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	NAS	J:51632
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IMP	J:107414
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IMP	J:107414
Biological Process	GO:0048839	inner ear development	IMP	J:107414
Biological Process	GO:0048839	inner ear development	IMP	J:107414
Biological Process	GO:0048839	inner ear development	IMP	J:107414
Biological Process	GO:0042472	inner ear morphogenesis	NAS	J:51632
Biological Process	GO:0046331	lateral inhibition	IDA	J:143172
Biological Process	GO:0046331	lateral inhibition	IMP	J:177887
Biological Process	GO:0070986	left/right axis specification	IMP	J:83358
Biological Process	GO:0072070	loop of Henle development	IEP	J:97734
Biological Process	GO:0002315	marginal zone B cell differentiation	IMP	J:146621
Biological Process	GO:0002315	marginal zone B cell differentiation	IMP	J:90630
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030099	myeloid cell differentiation	IDA	J:131628
Biological Process	GO:2000726	negative regulation of cardiac muscle cell differentiation	IMP	J:241479
Biological Process	GO:0045596	negative regulation of cell differentiation	IMP	J:220446
Biological Process	GO:0045596	negative regulation of cell differentiation	IMP	J:57072
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:135515
Biological Process	GO:0045605	negative regulation of epidermal cell differentiation	IMP	J:135515
Biological Process	GO:0030857	negative regulation of epithelial cell differentiation	IMP	J:177887
Biological Process	GO:0034351	negative regulation of glial cell apoptotic process	IMP	J:199717
Biological Process	GO:0045611	negative regulation of hemocyte differentiation	IDA	J:131628
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IMP	J:107414
Biological Process	GO:0032693	negative regulation of interleukin-10 production	ISO	J:164563
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	IDA	J:131628
Biological Process	GO:0045662	negative regulation of myoblast differentiation	IMP	J:119082
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:149456
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:156172
Biological Process	GO:0072006	nephron development	IMP	J:198632
Biological Process	GO:0007399	nervous system development	NAS	J:56816
Biological Process	GO:0060563	neuroepithelial cell differentiation	IMP	J:107414
Biological Process	GO:0060563	neuroepithelial cell differentiation	IMP	J:107414
Biological Process	GO:0030182	neuron differentiation	IMP	J:156172
Biological Process	GO:0048665	neuron fate specification	IDA	J:143172
Biological Process	GO:0097150	neuronal stem cell population maintenance	IMP	J:224724
Biological Process	GO:0061314	Notch signaling involved in heart development	IC	J:83358
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:149456
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:97734
Biological Process	GO:0007219	Notch signaling pathway	IEP	J:199717
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0060853	Notch signaling pathway involved in arterial endothelial cell fate commitment	IMP	J:148902
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	NAS	J:51928
Biological Process	GO:0035265	organ growth	IMP	J:178999
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:178999
Biological Process	GO:0045807	positive regulation of endocytosis	IDA	J:224738
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:65682
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IMP	J:177887
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:224738
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IMP	J:149456
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	ISO	J:155856
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IMP	J:148902
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:224861
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:88030
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IDA	J:97329
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	IMP	J:216287
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	IMP	J:192694
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:83358
Biological Process	GO:0072014	proximal tubule development	IEP	J:97734
Biological Process	GO:0009954	proximal/distal pattern formation	IMP	J:184814
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:150183
Biological Process	GO:0030155	regulation of cell adhesion	IMP	J:188916
Biological Process	GO:0051302	regulation of cell division	IMP	J:177887
Biological Process	GO:0040008	regulation of growth	IMP	J:150183
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:143172
Biological Process	GO:0050767	regulation of neurogenesis	IMP	J:149456
Biological Process	GO:0048631	regulation of skeletal muscle tissue growth	IMP	J:119082
Biological Process	GO:0014807	regulation of somitogenesis	IMP	J:224861
Biological Process	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	IMP	J:148902
Biological Process	GO:0060041	retina development in camera-type eye	IMP	J:149456
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	IMP	J:149456
Biological Process	GO:0048630	skeletal muscle tissue growth	IMP	J:188916
Biological Process	GO:0098773	skin epidermis development	IMP	J:135515
Biological Process	GO:0001757	somite specification	IMP	J:88580
Biological Process	GO:0001756	somitogenesis	IMP	J:205623
Biological Process	GO:0001756	somitogenesis	IGI	J:98581
Biological Process	GO:0021510	spinal cord development	IMP	J:149456
Biological Process	GO:0003323	type B pancreatic cell development	IMP	J:184814