GO Annotations Graph

• Symbol: Pml
• Name: promyelocytic leukemia
• ID: MGI:104662

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0050897	cobalt ion binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:245382
Molecular Function	GO:0005515	protein binding	IPI	J:266112
Molecular Function	GO:0005515	protein binding	IPI	J:184109
Molecular Function	GO:0005515	protein binding	IPI	J:166717
Molecular Function	GO:0005515	protein binding	IPI	J:181918
Molecular Function	GO:0005515	protein binding	IPI	J:205030
Molecular Function	GO:0005515	protein binding	IPI	J:181918
Molecular Function	GO:0005515	protein binding	IPI	J:182380
Molecular Function	GO:0005515	protein binding	IPI	J:154718
Molecular Function	GO:0005515	protein binding	IPI	J:111744
Molecular Function	GO:0005515	protein binding	IPI	J:92664
Molecular Function	GO:0005515	protein binding	IPI	J:111744
Molecular Function	GO:0005515	protein binding	IPI	J:98709
Molecular Function	GO:0005515	protein binding	IPI	J:81640
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	IDA	J:92664
Molecular Function	GO:0032183	SUMO binding	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	IBA	J:265628
Molecular Function	GO:0140037	sumo-dependent protein binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	TAS	J:98981
Molecular Function	GO:0003713	transcription coactivator activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Molecular Function	GO:0061659	ubiquitin-like protein ligase activity	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:166717
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0042406	extrinsic component of endoplasmic reticulum membrane	IDA	J:166717
Cellular Component	GO:0000792	heterochromatin	IDA	J:240279
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016363	nuclear matrix	ISO	J:164563
Cellular Component	GO:0016363	nuclear matrix	IDA	J:91881
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	IBA	J:265628
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:166717
Cellular Component	GO:0005634	nucleus	IDA	J:181918
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:240279
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:152281
Cellular Component	GO:0005634	nucleus	IDA	J:64959
Cellular Component	GO:0016605	PML body	IMP	J:123220
Cellular Component	GO:0016605	PML body	IBA	J:265628
Cellular Component	GO:0016605	PML body	IDA	J:199753
Cellular Component	GO:0016605	PML body	ISO	J:73065
Cellular Component	GO:0016605	PML body	IDA	J:105718
Cellular Component	GO:0016605	PML body	IDA	J:141678
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:50588
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:0060444	branching involved in mammary gland duct morphogenesis	IMP	J:147092
Biological Process	GO:0045165	cell fate commitment	IMP	J:147092
Biological Process	GO:0071353	cellular response to interleukin-4	IDA	J:62630
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0032922	circadian regulation of gene expression	IDA	J:181918
Biological Process	GO:0007182	common-partner SMAD protein phosphorylation	IMP	J:92664
Biological Process	GO:0051607	defense response to virus	IEA	J:60000
Biological Process	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP	J:98981
Biological Process	GO:0032469	endoplasmic reticulum calcium ion homeostasis	IMP	J:166717
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	IDA	J:181918
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	IMP	J:50588
Biological Process	GO:0010761	fibroblast migration	IMP	J:199373
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	ISO	J:164563
Biological Process	GO:0045087	innate immune response	IDA	J:205675
Biological Process	GO:0045087	innate immune response	IBA	J:265628
Biological Process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	IMP	J:88573
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	ISO	J:164563
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:50588
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:98981
Biological Process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP	J:98981
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP	J:166717
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:166717
Biological Process	GO:0051457	maintenance of protein location in nucleus	ISO	J:127492
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:46381
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	IMP	J:111744
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:46381
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0032691	negative regulation of interleukin-1 beta production	IMP	J:219619
Biological Process	GO:0032692	negative regulation of interleukin-1 production	IMP	J:219619
Biological Process	GO:0045930	negative regulation of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0051974	negative regulation of telomerase activity	ISO	J:164563
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0032938	negative regulation of translation in response to oxidative stress	ISO	J:164563
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0090402	oncogene-induced cell senescence	IMP	J:123219
Biological Process	GO:0030578	PML body organization	ISO	J:164563
Biological Process	GO:0030578	PML body organization	ISO	J:164563
Biological Process	GO:0030578	PML body organization	ISO	J:155856
Biological Process	GO:0030578	PML body organization	IDA	J:81640
Biological Process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	ISO	J:164563
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IGI	J:169813
Biological Process	GO:2001235	positive regulation of apoptotic signaling pathway	IMP	J:169813
Biological Process	GO:0002230	positive regulation of defense response to virus by host	ISO	J:164563
Biological Process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:199373
Biological Process	GO:0031065	positive regulation of histone deacetylation	ISO	J:164563
Biological Process	GO:2000758	positive regulation of peptidyl-lysine acetylation	IMP	J:123219
Biological Process	GO:1904816	positive regulation of protein localization to chromosome, telomeric region	ISO	J:164563
Biological Process	GO:1901798	positive regulation of signal transduction by p53 class mediator	IMP	J:123219
Biological Process	GO:0032206	positive regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0032206	positive regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0006606	protein import into nucleus	IMP	J:92664
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:0006605	protein targeting	ISO	J:164563
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0031503	protein-containing complex localization	IMP	J:92664
Biological Process	GO:0010522	regulation of calcium ion transport into cytosol	IMP	J:166717
Biological Process	GO:0030155	regulation of cell adhesion	IMP	J:199373
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IDA	J:181918
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2000779	regulation of double-strand break repair	ISO	J:164563
Biological Process	GO:0034097	response to cytokine	ISO	J:164563
Biological Process	GO:0010332	response to gamma radiation	IMP	J:119165
Biological Process	GO:0010332	response to gamma radiation	IMP	J:50588
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	IMP	J:111744
Biological Process	GO:0009411	response to UV	IMP	J:98981
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	IMP	J:46381
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0044790	suppression of viral release by host	ISO	J:164563
Biological Process	GO:0044790	suppression of viral release by host	IDA	J:205675
Biological Process	GO:0044790	suppression of viral release by host	IBA	J:265628
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	IMP	J:92664