GO Annotations Graph

• Symbol: Man2a1
• Name: mannosidase 2, alpha 1
• ID: MGI:104669

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004559	alpha-mannosidase activity	IBA	J:265628
Molecular Function	GO:0030246	carbohydrate binding	IEA	J:72247
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IDA	J:164482
Molecular Function	GO:0016798	hydrolase activity, acting on glycosyl bonds	IEA	J:60000
Molecular Function	GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	IDA	J:111055
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0015923	mannosidase activity	IDA	J:111055
Molecular Function	GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:155856
Cellular Component	GO:0005801	cis-Golgi network	IDA	J:188708
Cellular Component	GO:0005615	extracellular space	IDA	J:164482
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:193786
Cellular Component	GO:0005794	Golgi apparatus	IDA	J:104106
Cellular Component	GO:0005797	Golgi medial cisterna	ISO	J:164563
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0000139	Golgi membrane	IBA	J:265628
Cellular Component	GO:0000139	Golgi membrane	IDA	J:67373
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:72247
Biological Process	GO:0001701	in utero embryonic development	IGI	J:111055
Biological Process	GO:0001889	liver development	IGI	J:111055
Biological Process	GO:0048286	lung alveolus development	IGI	J:111055
Biological Process	GO:0006013	mannose metabolic process	IEA	J:72247
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0007005	mitochondrion organization	IGI	J:111055
Biological Process	GO:0007005	mitochondrion organization	IGI	J:111055
Biological Process	GO:0007005	mitochondrion organization	IGI	J:111055
Biological Process	GO:0006491	N-glycan processing	ISO	J:155856
Biological Process	GO:0006491	N-glycan processing	IBA	J:265628
Biological Process	GO:0006491	N-glycan processing	IGI	J:111055
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:160260
Biological Process	GO:0050769	positive regulation of neurogenesis	IMP	J:160260
Biological Process	GO:0006517	protein deglycosylation	IBA	J:265628
Biological Process	GO:0007585	respiratory gaseous exchange by respiratory system	IGI	J:111055
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	IMP	J:160260
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	IMP	J:160260
Biological Process	GO:0007033	vacuole organization	IGI	J:111055
Biological Process	GO:0007033	vacuole organization	IGI	J:111055
Biological Process	GO:0007033	vacuole organization	IGI	J:111055