GO Annotations Graph

• Symbol: Tfap2a
• Name: transcription factor AP-2, alpha
• ID: MGI:104671

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:92872
Molecular Function	GO:0003682	chromatin binding	IDA	J:131815
Molecular Function	GO:0003682	chromatin binding	IDA	J:131815
Molecular Function	GO:0003682	chromatin binding	IDA	J:131815
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	IDA	J:157160
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:175350
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:51610
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:157278
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:28698
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:72398
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:92872
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:105726
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:157160
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0140536	nuclear receptor corepressor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:76593
Molecular Function	GO:0005515	protein binding	IPI	J:72398
Molecular Function	GO:0005515	protein binding	IPI	J:227201
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:54843
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:126723
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:51610
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0003713	transcription coactivator activity	IDA	J:175832
Molecular Function	GO:0003714	transcription corepressor activity	IDA	J:175832
Cellular Component	GO:0005905	clathrin-coated pit	IDA	J:227201
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:155154
Cellular Component	GO:0005634	nucleus	IDA	J:143315
Cellular Component	GO:0005634	nucleus	IDA	J:63183
Cellular Component	GO:0005634	nucleus	IDA	J:143315
Cellular Component	GO:0005634	nucleus	IDA	J:131815
Cellular Component	GO:0005634	nucleus	IDA	J:105726
Cellular Component	GO:0005667	transcription regulator complex	TAS	J:72398
Biological Process	GO:0048856	anatomical structure development	IBA	J:265628
Biological Process	GO:0021506	anterior neuropore closure	IMP	J:33032
Biological Process	GO:0071711	basement membrane organization	IMP	J:103736
Biological Process	GO:0060349	bone morphogenesis	IMP	J:33031
Biological Process	GO:0008283	cell population proliferation	IMP	J:105726
Biological Process	GO:0071281	cellular response to iron ion	ISO	J:164563
Biological Process	GO:0061303	cornea development in camera-type eye	IMP	J:103736
Biological Process	GO:0061303	cornea development in camera-type eye	IMP	J:103736
Biological Process	GO:0010172	embryonic body morphogenesis	IMP	J:88783
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis	IMP	J:50932
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:33031
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IMP	J:33032
Biological Process	GO:0035115	embryonic forelimb morphogenesis	IMP	J:50932
Biological Process	GO:0009880	embryonic pattern specification	IMP	J:128903
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IMP	J:105726
Biological Process	GO:0048730	epidermis morphogenesis	IMP	J:105726
Biological Process	GO:0061029	eyelid development in camera-type eye	IMP	J:50932
Biological Process	GO:0060325	face morphogenesis	IMP	J:50932
Biological Process	GO:0010761	fibroblast migration	IMP	J:157278
Biological Process	GO:0021884	forebrain neuron development	IMP	J:61910
Biological Process	GO:0035136	forelimb morphogenesis	IMP	J:50932
Biological Process	GO:0042472	inner ear morphogenesis	ISO	J:164563
Biological Process	GO:0003334	keratinocyte development	IGI	J:143315
Biological Process	GO:0003334	keratinocyte development	IGI	J:143315
Biological Process	GO:0003334	keratinocyte development	IGI	J:143315
Biological Process	GO:0001822	kidney development	ISO	J:164563
Biological Process	GO:0060235	lens induction in camera-type eye	IMP	J:58477
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	IMP	J:52402
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	IMP	J:131815
Biological Process	GO:0072210	metanephric nephron development	IEP	J:28698
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:105726
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	IMP	J:105726
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IGI	J:173638
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	ISO	J:164563
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	ISO	J:164563
Biological Process	GO:0010944	negative regulation of transcription by competitive promoter binding	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:175832
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEP	J:28698
Biological Process	GO:0014032	neural crest cell development	IMP	J:33031
Biological Process	GO:0001843	neural tube closure	IMP	J:50932
Biological Process	GO:0001843	neural tube closure	IMP	J:33031
Biological Process	GO:0051402	neuron apoptotic process	IGI	J:173638
Biological Process	GO:0021623	oculomotor nerve formation	IMP	J:33031
Biological Process	GO:0003409	optic cup structural organization	IMP	J:158712
Biological Process	GO:0003404	optic vesicle morphogenesis	IMP	J:158712
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:73813
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:92872
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010763	positive regulation of fibroblast migration	IMP	J:157278
Biological Process	GO:0010628	positive regulation of gene expression	IDA	J:92872
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0070172	positive regulation of tooth mineralization	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:175350
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:51610
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:76593
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:54843
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:28698
Biological Process	GO:0045595	regulation of cell differentiation	ISO	J:164563
Biological Process	GO:0042127	regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:72398
Biological Process	GO:0045664	regulation of neuron differentiation	IMP	J:63183
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:92872
Biological Process	GO:0032496	response to lipopolysaccharide	ISO	J:155856
Biological Process	GO:0060021	roof of mouth development	ISO	J:164563
Biological Process	GO:0007423	sensory organ development	IEP	J:28698
Biological Process	GO:0007605	sensory perception of sound	ISO	J:164563
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:33032
Biological Process	GO:0043588	skin development	IEP	J:28698
Biological Process	GO:0043588	skin development	IGI	J:143315
Biological Process	GO:0043588	skin development	IGI	J:143315
Biological Process	GO:0043588	skin development	IGI	J:143315
Biological Process	GO:0048485	sympathetic nervous system development	IGI	J:173638
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:76593
Biological Process	GO:0021559	trigeminal nerve development	IMP	J:33031