GO Annotations Graph

• Symbol: Hgs
• Name: HGF-regulated tyrosine kinase substrate
• ID: MGI:104681

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	IPI	J:247437
Molecular Function	GO:0046872	metal ion binding	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0035091	phosphatidylinositol binding	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:220514
Molecular Function	GO:0005515	protein binding	IPI	J:224742
Molecular Function	GO:0005515	protein binding	IPI	J:245341
Molecular Function	GO:0005515	protein binding	IPI	J:224743
Molecular Function	GO:0005515	protein binding	IPI	J:166236
Molecular Function	GO:0005515	protein binding	IPI	J:165406
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0043130	ubiquitin binding	IBA	J:265628
Molecular Function	GO:0140036	ubiquitin-dependent protein binding	IDA	J:219110
Molecular Function	GO:0044389	ubiquitin-like protein ligase binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:29402
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IBA	J:265628
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0033565	ESCRT-0 complex	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Biological Process	GO:0032456	endocytic recycling	IBA	J:265628
Biological Process	GO:0008333	endosome to lysosome transport	ISO	J:155856
Biological Process	GO:0010324	membrane invagination	ISO	J:164563
Biological Process	GO:0016525	negative regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:1903543	positive regulation of exosomal secretion	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0072657	protein localization to membrane	ISO	J:164563
Biological Process	GO:0006622	protein targeting to lysosome	ISO	J:164563
Biological Process	GO:0015031	protein transport	IEA	J:60000
Biological Process	GO:0031623	receptor internalization	IBA	J:265628
Biological Process	GO:0043405	regulation of MAP kinase activity	ISO	J:164563