GO Annotations Graph

• Symbol: Eps8
• Name: epidermal growth factor receptor pathway substrate 8
• ID: MGI:104684

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	IDA	J:196111
Molecular Function	GO:0003779	actin binding	IDA	J:196125
Molecular Function	GO:0003779	actin binding	IDA	J:161597
Molecular Function	GO:0003779	actin binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:137488
Molecular Function	GO:0005515	protein binding	IPI	J:171832
Molecular Function	GO:0005515	protein binding	IPI	J:150646
Molecular Function	GO:0005515	protein binding	IPI	J:195223
Molecular Function	GO:0005515	protein binding	IPI	J:114805
Molecular Function	GO:0005515	protein binding	IPI	J:196106
Molecular Function	GO:0005515	protein binding	IPI	J:155180
Molecular Function	GO:0005515	protein binding	IPI	J:196111
Molecular Function	GO:0005515	protein binding	IPI	J:196125
Molecular Function	GO:0005515	protein binding	IPI	J:116055
Molecular Function	GO:0005515	protein binding	IPI	J:148808
Molecular Function	GO:0005515	protein binding	IPI	J:116055
Molecular Function	GO:0035591	signaling adaptor activity	IEA	J:72247
Molecular Function	GO:0031267	small GTPase binding	IDA	J:196125
Cellular Component	GO:0005903	brush border	IDA	J:219622
Cellular Component	GO:0005938	cell cortex	IDA	J:196125
Cellular Component	GO:0005938	cell cortex	IDA	J:195223
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9659536
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9663360
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:237769
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:237769
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:237769
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:237769
Cellular Component	GO:0098978	glutamatergic synapse	IEP	J:237769
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043005	neuron projection	IEA	J:60000
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	IDA	J:116055
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	IDA	J:116055
Cellular Component	GO:0032587	ruffle membrane	IDA	J:196125
Cellular Component	GO:0032587	ruffle membrane	IBA	J:265628
Cellular Component	GO:0032420	stereocilium	IDA	J:215946
Cellular Component	GO:0032420	stereocilium	IDA	J:171832
Cellular Component	GO:0032421	stereocilium bundle	IDA	J:200669
Cellular Component	GO:0032426	stereocilium tip	IDA	J:200669
Cellular Component	GO:0045202	synapse	IDA	J:116055
Biological Process	GO:0051764	actin crosslink formation	IMP	J:196106
Biological Process	GO:0051764	actin crosslink formation	IDA	J:161597
Biological Process	GO:0030036	actin cytoskeleton organization	IMP	J:116055
Biological Process	GO:0051017	actin filament bundle assembly	IMP	J:196106
Biological Process	GO:0051017	actin filament bundle assembly	IDA	J:161597
Biological Process	GO:0051017	actin filament bundle assembly	IGI	J:148808
Biological Process	GO:0070358	actin polymerization-dependent cell motility	IDA	J:196111
Biological Process	GO:0008344	adult locomotory behavior	IMP	J:116055
Biological Process	GO:0051016	barbed-end actin filament capping	IDA	J:196111
Biological Process	GO:0051016	barbed-end actin filament capping	IMP	J:195223
Biological Process	GO:0051016	barbed-end actin filament capping	IDA	J:161597
Biological Process	GO:0048149	behavioral response to ethanol	IMP	J:116055
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0036336	dendritic cell migration	IMP	J:176428
Biological Process	GO:0010458	exit from mitosis	IMP	J:195223
Biological Process	GO:1900029	positive regulation of ruffle assembly	IBA	J:265628
Biological Process	GO:0016601	Rac protein signal transduction	IDA	J:196125
Biological Process	GO:0030832	regulation of actin filament length	IMP	J:171832
Biological Process	GO:0008360	regulation of cell shape	IMP	J:195223
Biological Process	GO:0008360	regulation of cell shape	IMP	J:196106
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IEP	J:237769
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	J:237769
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	J:237769
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	EXP	J:237769
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	IDA	J:237769
Biological Process	GO:0035023	regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0007266	Rho protein signal transduction	IBA	J:265628