GO Annotations Graph

• Symbol: Cplx2
• Name: complexin 2
• ID: MGI:104726

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048306	calcium-dependent protein binding	ISO	J:155856
Molecular Function	GO:0000149	SNARE binding	ISO	J:155856
Molecular Function	GO:0000149	SNARE binding	IBA	J:265628
Molecular Function	GO:0019905	syntaxin binding	IEA	J:72247
Molecular Function	GO:0017075	syntaxin-1 binding	ISO	J:29256
Cellular Component	GO:0044305	calyx of Held	IDA	J:222237
Cellular Component	GO:0044305	calyx of Held	IDA	J:222237
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0030425	dendrite	ISO	J:29256
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:86365
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:86365
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:86365
Cellular Component	GO:0043025	neuronal cell body	ISO	J:29256
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:0098793	presynapse	IDA	J:222237
Cellular Component	GO:0098793	presynapse	IDA	J:222237
Cellular Component	GO:0031201	SNARE complex	ISO	J:155856
Cellular Component	GO:0031201	SNARE complex	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:29256
Cellular Component	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex	ISO	J:155856
Cellular Component	GO:0043195	terminal bouton	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0006887	exocytosis	IEA	J:60000
Biological Process	GO:0043303	mast cell degranulation	IEA	J:60000
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0006836	neurotransmitter transport	IEA	J:72247
Biological Process	GO:0006836	neurotransmitter transport	IEA	J:60000
Biological Process	GO:0031915	positive regulation of synaptic plasticity	IDA	J:172950
Biological Process	GO:0046928	regulation of neurotransmitter secretion	IBA	J:265628
Biological Process	GO:0031630	regulation of synaptic vesicle fusion to presynaptic active zone membrane	IDA	J:86365
Biological Process	GO:0031630	regulation of synaptic vesicle fusion to presynaptic active zone membrane	IDA	J:86365
Biological Process	GO:0031630	regulation of synaptic vesicle fusion to presynaptic active zone membrane	IMP	J:86365
Biological Process	GO:0016079	synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0016079	synaptic vesicle exocytosis	IBA	J:265628