Cdkn2a GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cdkn2a
cyclin dependent kinase inhibitor 2A
MGI:104738

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	ISO	J:24521
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:77997
Molecular Function	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	J:28319
Molecular Function	GO:0097718	disordered domain specific binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	IPI	J:72910
Molecular Function	GO:0097371	MDM2/MDM4 family protein binding	ISO	J:164563
Molecular Function	GO:0051059	NF-kappaB binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:143694
Molecular Function	GO:0005515	protein binding	IPI	J:296094
Molecular Function	GO:0005515	protein binding	IPI	J:171888
Molecular Function	GO:0005515	protein binding	IPI	J:189986
Molecular Function	GO:0005515	protein binding	IPI	J:207374
Molecular Function	GO:0005515	protein binding	IPI	J:193629
Molecular Function	GO:0005515	protein binding	IPI	J:94162
Molecular Function	GO:0005515	protein binding	IPI	J:94174
Molecular Function	GO:0005515	protein binding	IPI	J:94174
Molecular Function	GO:0005515	protein binding	IPI	J:99711
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0019789	SUMO transferase activity	ISO	J:164563
Molecular Function	GO:1990948	ubiquitin ligase inhibitor activity	ISO	J:164563
Molecular Function	GO:0055105	ubiquitin-protein transferase inhibitor activity	IDA	J:51904
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:79357
Cellular Component	GO:0001652	granular component	IDA	J:79357
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:94162
Cellular Component	GO:0005730	nucleolus	IDA	J:94174
Cellular Component	GO:0005730	nucleolus	IDA	J:72910
Cellular Component	GO:0005730	nucleolus	IDA	J:101353
Cellular Component	GO:0005730	nucleolus	IDA	J:138546
Cellular Component	GO:0005730	nucleolus	IDA	J:99711
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	IMP	J:72910
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0035985	senescence-associated heterochromatin focus	ISO	J:164563
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:1990000	amyloid fibril formation	ISO	J:164563
Biological Process	GO:0008637	apoptotic mitochondrial changes	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IEA	J:72247
Biological Process	GO:0060057	apoptotic process involved in mammary gland involution	IMP	J:91428
Biological Process	GO:0000422	autophagy of mitochondrion	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IDA	J:94174
Biological Process	GO:0070301	cellular response to hydrogen peroxide	IDA	J:198334
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	ISO	J:164563
Biological Process	GO:0090398	cellular senescence	IMP	J:178645
Biological Process	GO:0090398	cellular senescence	IGI	J:72780
Biological Process	GO:0090398	cellular senescence	IDA	J:190763
Biological Process	GO:0090398	cellular senescence	IDA	J:74741
Biological Process	GO:0008544	epidermis development	IMP	J:72780
Biological Process	GO:0008544	epidermis development	IGI	J:72780
Biological Process	GO:0042593	glucose homeostasis	IMP	J:209560
Biological Process	GO:0042593	glucose homeostasis	IMP	J:209560
Biological Process	GO:0030216	keratinocyte differentiation	IGI	J:72780
Biological Process	GO:0043616	keratinocyte proliferation	IGI	J:72780
Biological Process	GO:0033598	mammary gland epithelial cell proliferation	IMP	J:91428
Biological Process	GO:0051882	mitochondrial depolarization	ISO	J:164563
Biological Process	GO:0030889	negative regulation of B cell proliferation	IMP	J:105559
Biological Process	GO:0045786	negative regulation of cell cycle	IDA	J:94174
Biological Process	GO:0030308	negative regulation of cell growth	ISO	J:164563
Biological Process	GO:0030308	negative regulation of cell growth	IMP	J:79357
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:24521
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:77997
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:2000346	negative regulation of hepatocyte proliferation	ISO	J:155856
Biological Process	GO:0033088	negative regulation of immature T cell proliferation in thymus	IMP	J:105559
Biological Process	GO:0033600	negative regulation of mammary gland epithelial cell proliferation	IMP	J:91428
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0042326	negative regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0032091	negative regulation of protein binding	IDA	J:193629
Biological Process	GO:0006469	negative regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:2000435	negative regulation of protein neddylation	ISO	J:164563
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	ISO	J:164563
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	IDA	J:193629
Biological Process	GO:1904667	negative regulation of ubiquitin protein ligase activity	ISO	J:164563
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	IDA	J:193629
Biological Process	GO:0051444	negative regulation of ubiquitin-protein transferase activity	IDA	J:51904
Biological Process	GO:0090402	oncogene-induced cell senescence	IMP	J:72780
Biological Process	GO:0090402	oncogene-induced cell senescence	IGI	J:72780
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	IMP	J:91428
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	IC	J:51904
Biological Process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IMP	J:144234
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:144234
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:2000111	positive regulation of macrophage apoptotic process	IGI	J:170042
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:164563
Biological Process	GO:0033235	positive regulation of protein sumoylation	ISO	J:164563
Biological Process	GO:1901798	positive regulation of signal transduction by p53 class mediator	ISO	J:164563
Biological Process	GO:0034393	positive regulation of smooth muscle cell apoptotic process	IGI	J:170042
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:164563
Biological Process	GO:0050821	protein stabilization	ISO	J:164563
Biological Process	GO:1902510	regulation of apoptotic DNA fragmentation	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	ISO	J:164563
Biological Process	GO:0051726	regulation of cell cycle	IDA	J:28319
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	J:28319
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	IGI	J:79357
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:70387
Biological Process	GO:0010468	regulation of gene expression	IMP	J:70387
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	IGI	J:94174
Biological Process	GO:0046825	regulation of protein export from nucleus	ISO	J:164563
Biological Process	GO:0031647	regulation of protein stability	IMP	J:79357
Biological Process	GO:1903214	regulation of protein targeting to mitochondrion	ISO	J:164563
Biological Process	GO:0090399	replicative senescence	ISO	J:164563
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0010243	response to organonitrogen compound	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0006364	rRNA processing	IEA	J:60000
Biological Process	GO:0009303	rRNA transcription	IGI	J:142821
Biological Process	GO:0048103	somatic stem cell division	IMP	J:105559
Biological Process	GO:0035019	somatic stem cell population maintenance	IGI	J:144068

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