GO Annotations Graph

• Symbol: Pkia
• Name: protein kinase inhibitor, alpha
• ID: MGI:104747

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	IBA	J:265628
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	IDA	J:41726
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	ISO	J:135400
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:245325
Molecular Function	GO:0005515	protein binding	IPI	J:292521
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	IPI	J:240313
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0004860	protein kinase inhibitor activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	IDA	J:23206
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:23206
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	IBA	J:265628
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	ISO	J:135400
Biological Process	GO:0043086	negative regulation of catalytic activity	IDA	J:23206
Biological Process	GO:0042308	negative regulation of protein import into nucleus	IDA	J:41726
Biological Process	GO:0006469	negative regulation of protein kinase activity	IDA	J:41726
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:41726
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	IMP	J:23206