GO Annotations Graph

• Symbol: Sik1
• Name: salt inducible kinase 1
• ID: MGI:104754

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IDA	J:90713
Molecular Function	GO:0008140	cAMP response element binding protein binding	IDA	J:79888
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:121892
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:90713
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:177249
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	IPI	J:79888
Molecular Function	GO:0019901	protein kinase binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:102116
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:90713
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:121892
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:177249
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:83587
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:121527
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:79888
Cellular Component	GO:0005737	cytoplasm	IDA	J:90713
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:121527
Cellular Component	GO:0005634	nucleus	IDA	J:79888
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:83587
Biological Process	GO:0043276	anoikis	IMP	J:168286
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:158005
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	IMP	J:204540
Biological Process	GO:0035556	intracellular signal transduction	IDA	J:90713
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	IMP	J:204540
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	IDA	J:102116
Biological Process	GO:0032792	negative regulation of CREB transcription factor activity	IDA	J:79888
Biological Process	GO:0045721	negative regulation of gluconeogenesis	IDA	J:102116
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0010868	negative regulation of triglyceride biosynthetic process	IDA	J:177249
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:2000210	positive regulation of anoikis	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IDA	J:90713
Biological Process	GO:0006468	protein phosphorylation	IDA	J:204540
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:83587
Biological Process	GO:0045595	regulation of cell differentiation	IEP	J:90713
Biological Process	GO:0007346	regulation of mitotic cell cycle	IDA	J:90713
Biological Process	GO:0010830	regulation of myotube differentiation	IDA	J:121892
Biological Process	GO:0002028	regulation of sodium ion transport	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000