GO Annotations Graph

• Symbol: Gpx4
• Name: glutathione peroxidase 4
• ID: MGI:104767

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004602	glutathione peroxidase activity	ISO	J:155856
Molecular Function	GO:0004602	glutathione peroxidase activity	ISO	J:164563
Molecular Function	GO:0004602	glutathione peroxidase activity	IDA	J:158033
Molecular Function	GO:0004602	glutathione peroxidase activity	ISO	J:69361
Molecular Function	GO:0004602	glutathione peroxidase activity	IDA	J:69361
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0004601	peroxidase activity	IBA	J:265628
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	IDA	J:217747
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	IDA	J:255340
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	ISO	J:164563
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	ISO	J:155856
Molecular Function	GO:0008430	selenium binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	IDA	J:158033
Cellular Component	GO:0005829	cytosol	IDA	J:82053
Cellular Component	GO:0005743	mitochondrial inner membrane	HDA	J:100953
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:100834
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:82053
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005635	nuclear envelope	IDA	J:82053
Cellular Component	GO:0005634	nucleus	IDA	J:69361
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0006325	chromatin organization	IDA	J:69361
Biological Process	GO:0006749	glutathione metabolic process	ISO	J:155856
Biological Process	GO:0006629	lipid metabolic process	IEA	J:60000
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0110076	negative regulation of ferroptosis	IMP	J:217747
Biological Process	GO:0110076	negative regulation of ferroptosis	IMP	J:255340
Biological Process	GO:0051258	protein polymerization	ISO	J:164563
Biological Process	GO:0050727	regulation of inflammatory response	ISO	J:155856
Biological Process	GO:0006979	response to oxidative stress	IMP	J:217747
Biological Process	GO:0006979	response to oxidative stress	IMP	J:255340
Biological Process	GO:0007283	spermatogenesis	IMP	J:225651
Biological Process	GO:0007283	spermatogenesis	IDA	J:69361