GO Annotations Graph

• Symbol: Erbb4
• Name: erb-b2 receptor tyrosine kinase 4
• ID: MGI:104771

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005006	epidermal growth factor receptor activity	IGI	J:82728
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:164563
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IBA	J:265628
Molecular Function	GO:0050811	GABA receptor binding	IDA	J:202968
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0038132	neuregulin binding	ISO	J:32778
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:34905
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:247763
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:42826
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:42826
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:314758
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:247763
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:306781
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:314758
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:314758
Molecular Function	GO:0038131	neuregulin receptor activity	ISO	J:223042
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:42983
Molecular Function	GO:0038131	neuregulin receptor activity	IMP	J:157327
Molecular Function	GO:0038131	neuregulin receptor activity	IDA	J:34905
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:177160
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	J:317052
Cellular Component	GO:0009925	basal plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0005901	caveola	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IMP	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098982	GABA-ergic synapse	IDA	J:159459
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:159459
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:159459
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:159459
Cellular Component	GO:0060077	inhibitory synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0031594	neuromuscular junction	IMP	J:180660
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:180660
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:202968
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:316875
Cellular Component	GO:0005886	plasma membrane	ISO	J:42826
Cellular Component	GO:0005886	plasma membrane	ISO	J:42826
Cellular Component	GO:0005886	plasma membrane	ISO	J:314758
Cellular Component	GO:0005886	plasma membrane	IDA	J:274112
Cellular Component	GO:0005886	plasma membrane	IDA	J:306781
Cellular Component	GO:0005886	plasma membrane	ISO	J:314758
Cellular Component	GO:0005886	plasma membrane	ISO	J:223042
Cellular Component	GO:0005886	plasma membrane	ISO	J:314758
Cellular Component	GO:0005886	plasma membrane	IDA	J:82728
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IDA	J:42983
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:317052
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:202968
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:159459
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:159459
Cellular Component	GO:0098839	postsynaptic density membrane	IDA	J:159459
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:159459
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:159459
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:159459
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:217137
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:217137
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0061026	cardiac muscle tissue regeneration	IMP	J:157327
Biological Process	GO:0045165	cell fate commitment	IDA	J:80421
Biological Process	GO:0016477	cell migration	ISO	J:164563
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:202968
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	IDA	J:34905
Biological Process	GO:0021551	central nervous system morphogenesis	IMP	J:60190
Biological Process	GO:0009880	embryonic pattern specification	IMP	J:60190
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IGI	J:82728
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IDA	J:47407
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IDA	J:34905
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:42826
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038130	ERBB4 signaling pathway	IMP	J:247763
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038130	ERBB4 signaling pathway	IMP	J:106042
Biological Process	GO:0038130	ERBB4 signaling pathway	ISO	J:223042
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:247763
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:34905
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:42826
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	ISO	J:314758
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:306781
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:47407
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:42983
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	IDA	J:317052
Biological Process	GO:0072046	establishment of planar polarity involved in nephron morphogenesis	IMP	J:180153
Biological Process	GO:0007507	heart development	IMP	J:29972
Biological Process	GO:0007595	lactation	IMP	J:178286
Biological Process	GO:0007595	lactation	ISO	J:164563
Biological Process	GO:0060749	mammary gland alveolus development	IMP	J:178286
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	IMP	J:114489
Biological Process	GO:0043653	mitochondrial fragmentation involved in apoptotic process	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0007399	nervous system development	IMP	J:29972
Biological Process	GO:0001755	neural crest cell migration	IMP	J:60190
Biological Process	GO:0022008	neurogenesis	IBA	J:265628
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:180660
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:180660
Biological Process	GO:0021889	olfactory bulb interneuron differentiation	IMP	J:95821
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0060045	positive regulation of cardiac muscle cell proliferation	IMP	J:157327
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:114489
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:155856
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IGI	J:136701
Biological Process	GO:0071073	positive regulation of phospholipid biosynthetic process	ISO	J:155856
Biological Process	GO:2000010	positive regulation of protein localization to cell surface	IGI	J:136701
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	ISO	J:164563
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IMP	J:114489
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	ISO	J:155856
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:114489
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:178286
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0030334	regulation of cell migration	IMP	J:95821
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0043129	surfactant homeostasis	ISO	J:155856
Biological Process	GO:0007416	synapse assembly	IDA	J:159459
Biological Process	GO:0007416	synapse assembly	IMP	J:159459
Biological Process	GO:0007416	synapse assembly	IDA	J:159459
Biological Process	GO:0060074	synapse maturation	ISO	J:155856
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628