GO Annotations Graph

• Symbol: Cdk2
• Name: cyclin dependent kinase 2
• ID: MGI:104772

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:155856
Molecular Function	GO:0030332	cyclin binding	IDA	J:211957
Molecular Function	GO:0030332	cyclin binding	IBA	J:265628
Molecular Function	GO:0030332	cyclin binding	IPI	J:105978
Molecular Function	GO:0030332	cyclin binding	IPI	J:105978
Molecular Function	GO:0097472	cyclin-dependent protein kinase activity	ISO	J:164563
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IDA	J:85809
Molecular Function	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	IDA	J:85481
Molecular Function	GO:0035173	histone kinase activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IDA	J:78410
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:263437
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:155178
Molecular Function	GO:0005515	protein binding	IPI	J:154868
Molecular Function	GO:0005515	protein binding	IPI	J:158603
Molecular Function	GO:0005515	protein binding	IPI	J:219103
Molecular Function	GO:0005515	protein binding	IPI	J:211957
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0005515	protein binding	IPI	J:19218
Molecular Function	GO:0005515	protein binding	IPI	J:239544
Molecular Function	GO:0005515	protein binding	IPI	J:78410
Molecular Function	GO:0005515	protein binding	IPI	J:85809
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IDA	J:239544
Molecular Function	GO:0004672	protein kinase activity	IDA	J:174697
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:263437
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0015030	Cajal body	ISO	J:164563
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:270644
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:239544
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:125220
Cellular Component	GO:0000793	condensed chromosome	IDA	J:125220
Cellular Component	GO:0097123	cyclin A1-CDK2 complex	IDA	J:24521
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	ISO	J:164563
Cellular Component	GO:0097124	cyclin A2-CDK2 complex	IDA	J:24521
Cellular Component	GO:0097134	cyclin E1-CDK2 complex	IDA	J:24521
Cellular Component	GO:0097135	cyclin E2-CDK2 complex	IDA	J:24521
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	ISO	J:164563
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IBA	J:265628
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IPI	J:85809
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:215796
Cellular Component	GO:0005635	nuclear envelope	IDA	J:239544
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-1013867
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:154868
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:53930
Cellular Component	GO:0000805	X chromosome	IDA	J:125220
Cellular Component	GO:0000806	Y chromosome	IDA	J:125220
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:155856
Biological Process	GO:0007099	centriole replication	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006351	DNA-templated transcription	IGI	J:103442
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	IDA	J:85481
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:26103
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:164563
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IDA	J:263437
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:235253
Biological Process	GO:0032298	positive regulation of DNA-templated DNA replication initiation	IGI	J:158674
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IGI	J:103442
Biological Process	GO:0031453	positive regulation of heterochromatin formation	ISO	J:164563
Biological Process	GO:0043687	post-translational protein modification	ISO	J:164563
Biological Process	GO:0006813	potassium ion transport	IGI	J:116872
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0006468	protein phosphorylation	IDA	J:78410
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	IBA	J:265628
Biological Process	GO:0010468	regulation of gene expression	IBA	J:265628
Biological Process	GO:0051591	response to cAMP	ISO	J:155856
Biological Process	GO:0051602	response to electrical stimulus	ISO	J:155856
Biological Process	GO:0010033	response to organic substance	IBA	J:265628
Biological Process	GO:0007165	signal transduction	IBA	J:265628