GO Annotations Graph

• Symbol: Adra1a
• Name: adrenergic receptor, alpha 1a
• ID: MGI:104773

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004935	adrenergic receptor activity	IEA	J:72247
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	ISO	J:155856
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	IBA	J:265628
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	ISO	J:69078
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	IDA	J:47838
Molecular Function	GO:0004937	alpha1-adrenergic receptor activity	IMP	J:83876
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0098691	dopaminergic synapse	ISO	J:155856
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:47838
Cellular Component	GO:0031965	nuclear membrane	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Cellular Component	GO:0030315	T-tubule	ISO	J:155856
Cellular Component	GO:0030018	Z disc	ISO	J:155856
Biological Process	GO:0007202	activation of phospholipase C activity	ISO	J:155856
Biological Process	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	IBA	J:265628
Biological Process	GO:0071875	adrenergic receptor signaling pathway	ISO	J:69078
Biological Process	GO:0007512	adult heart development	IGI	J:83876
Biological Process	GO:0007568	aging	ISO	J:155856
Biological Process	GO:0060402	calcium ion transport into cytosol	ISO	J:155856
Biological Process	GO:0061049	cell growth involved in cardiac muscle cell development	IGI	J:83876
Biological Process	GO:0007267	cell-cell signaling	IBA	J:265628
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0000165	MAPK cascade	IGI	J:83876
Biological Process	GO:0060073	micturition	ISO	J:155856
Biological Process	GO:0010507	negative regulation of autophagy	IDA	J:240718
Biological Process	GO:0001985	negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	IMP	J:77732
Biological Process	GO:0035024	negative regulation of Rho protein signal transduction	ISO	J:136004
Biological Process	GO:0150099	neuron-glial cell signaling	IGI	J:273582
Biological Process	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IMP	J:77732
Biological Process	GO:0035265	organ growth	IGI	J:83876
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IDA	J:47383
Biological Process	GO:0097195	pilomotor reflex	IDA	J:170886
Biological Process	GO:0045760	positive regulation of action potential	ISO	J:155856
Biological Process	GO:0060452	positive regulation of cardiac muscle contraction	ISO	J:155856
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	IDA	J:240718
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0010460	positive regulation of heart rate	ISO	J:155856
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IBA	J:265628
Biological Process	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine	IGI	J:83876
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IGI	J:83876
Biological Process	GO:1903997	positive regulation of non-membrane spanning protein tyrosine kinase activity	IDA	J:240718
Biological Process	GO:0090037	positive regulation of protein kinase C signaling	ISO	J:155856
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	ISO	J:155856
Biological Process	GO:0045987	positive regulation of smooth muscle contraction	IDA	J:170886
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	ISO	J:155856
Biological Process	GO:0003084	positive regulation of systemic arterial blood pressure	ISO	J:155856
Biological Process	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine	IGI	J:83036
Biological Process	GO:0045907	positive regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0045907	positive regulation of vasoconstriction	IBA	J:265628
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0008217	regulation of blood pressure	IMP	J:255410
Biological Process	GO:0055117	regulation of cardiac muscle contraction	IEA	J:72247
Biological Process	GO:0006937	regulation of muscle contraction	IEA	J:72247
Biological Process	GO:0019229	regulation of vasoconstriction	IEA	J:72247
Biological Process	GO:0009725	response to hormone	ISO	J:155856
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000