Prkdc GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Prkdc
protein kinase, DNA activated, catalytic polypeptide
MGI:104779

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	ISO	J:73065
Molecular Function	GO:0004677	DNA-dependent protein kinase activity	IDA	J:204750
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0003690	double-stranded DNA binding	IDA	J:173439
Molecular Function	GO:0019899	enzyme binding	IPI	J:168151
Molecular Function	GO:0016301	kinase activity	IEA	J:72247
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0140678	molecular function inhibitor activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:207239
Molecular Function	GO:0005515	protein binding	IPI	J:212794
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0034511	U3 snoRNA binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0070418	DNA-dependent protein kinase complex	ISO	J:164563
Cellular Component	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex	ISO	J:73065
Cellular Component	GO:0070419	nonhomologous end joining complex	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:82010
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0032040	small-subunit processome	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Biological Process	GO:0002218	activation of innate immune response	ISO	J:164563
Biological Process	GO:0002326	B cell lineage commitment	IMP	J:31364
Biological Process	GO:0002326	B cell lineage commitment	IMP	J:31364
Biological Process	GO:0002326	B cell lineage commitment	IMP	J:31364
Biological Process	GO:0007420	brain development	IGI	J:108789
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IBA	J:265628
Biological Process	GO:0006302	double-strand break repair	IMP	J:73443
Biological Process	GO:0006302	double-strand break repair	IMP	J:82010
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	NAS	J:320262
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:204750
Biological Process	GO:0035234	ectopic germ cell programmed cell death	IMP	J:118902
Biological Process	GO:0007507	heart development	IGI	J:108789
Biological Process	GO:0002327	immature B cell differentiation	IMP	J:50222
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IBA	J:265628
Biological Process	GO:0033152	immunoglobulin V(D)J recombination	IMP	J:50222
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IBA	J:265628
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:82010
Biological Process	GO:0030098	lymphocyte differentiation	IMP	J:17426
Biological Process	GO:0000460	maturation of 5.8S rRNA	ISO	J:164563
Biological Process	GO:0031571	mitotic G1 DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:155856
Biological Process	GO:0002638	negative regulation of immunoglobulin production	ISO	J:155856
Biological Process	GO:0045824	negative regulation of innate immune response	ISO	J:164563
Biological Process	GO:0001933	negative regulation of protein phosphorylation	IMP	J:207239
Biological Process	GO:2001229	negative regulation of response to gamma radiation	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	ISO	J:73065
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043065	positive regulation of apoptotic process	IMP	J:118902
Biological Process	GO:0048639	positive regulation of developmental growth	ISO	J:155856
Biological Process	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	IMP	J:287062
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0002684	positive regulation of immune system process	ISO	J:155856
Biological Process	GO:0045621	positive regulation of lymphocyte differentiation	IMP	J:287062
Biological Process	GO:1905221	positive regulation of platelet formation	IMP	J:287062
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	IMP	J:287062
Biological Process	GO:0002328	pro-B cell differentiation	IMP	J:50222
Biological Process	GO:0031648	protein destabilization	IDA	J:92391
Biological Process	GO:0006468	protein phosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:207239
Biological Process	GO:0050678	regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:1902036	regulation of hematopoietic stem cell differentiation	IMP	J:287062
Biological Process	GO:0048660	regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0010332	response to gamma radiation	IMP	J:50222
Biological Process	GO:0010212	response to ionizing radiation	IMP	J:173439
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0042254	ribosome biogenesis	IEA	J:60000
Biological Process	GO:0034462	small-subunit processome assembly	ISO	J:164563
Biological Process	GO:0001756	somitogenesis	IGI	J:108789
Biological Process	GO:0048536	spleen development	ISO	J:155856
Biological Process	GO:0033077	T cell differentiation in thymus	IMP	J:50222
Biological Process	GO:0002360	T cell lineage commitment	IMP	J:31364
Biological Process	GO:0002360	T cell lineage commitment	IMP	J:31364
Biological Process	GO:0002360	T cell lineage commitment	IMP	J:31364
Biological Process	GO:0033153	T cell receptor V(D)J recombination	IMP	J:50222
Biological Process	GO:0016233	telomere capping	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IBA	J:265628
Biological Process	GO:0000723	telomere maintenance	IMP	J:88560
Biological Process	GO:0048538	thymus development	ISO	J:155856
Biological Process	GO:0033151	V(D)J recombination	IGI	J:204750

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24