GO Annotations Graph

• Symbol: Ier3
• Name: immediate early response 3
• ID: MGI:104814

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005515	protein binding	IPI	J:158073
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:186356
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Biological Process	GO:0006974	DNA damage response	IBA	J:265628
Biological Process	GO:0006974	DNA damage response	ISO	J:73065
Biological Process	GO:0006974	DNA damage response	IMP	J:186356
Biological Process	GO:0006096	glycolytic process	IMP	J:158073
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IDA	J:132165
Biological Process	GO:0007095	mitotic G2 DNA damage checkpoint signaling	IMP	J:186356
Biological Process	GO:0043066	negative regulation of apoptotic process	IEA	J:72247
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:158073
Biological Process	GO:0050728	negative regulation of inflammatory response	IMP	J:157504
Biological Process	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IDA	J:158073
Biological Process	GO:0003085	negative regulation of systemic arterial blood pressure	IMP	J:131099
Biological Process	GO:0045732	positive regulation of protein catabolic process	IDA	J:158073
Biological Process	GO:0006282	regulation of DNA repair	IMP	J:186356
Biological Process	GO:0046822	regulation of nucleocytoplasmic transport	IMP	J:186356
Biological Process	GO:2000377	regulation of reactive oxygen species metabolic process	IDA	J:158073
Biological Process	GO:0001562	response to protozoan	IMP	J:157504