GO Annotations Graph

• Symbol: Akt2
• Name: thymoma viral proto-oncogene 2
• ID: MGI:104874

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:113933
Molecular Function	GO:0005515	protein binding	IPI	J:225409
Molecular Function	GO:0005515	protein binding	IPI	J:145864
Molecular Function	GO:0005515	protein binding	IPI	J:213891
Molecular Function	GO:0005515	protein binding	IPI	J:183035
Molecular Function	GO:0005515	protein binding	IPI	J:213903
Molecular Function	GO:0004672	protein kinase activity	IDA	J:176652
Molecular Function	GO:0005080	protein kinase C binding	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:155856
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	EXP	J:231278
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IBA	J:265628
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IDA	J:182891
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0005938	cell cortex	IMP	J:176652
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0032593	insulin-responsive compartment	ISO	J:155856
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IMP	J:176652
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1445150
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1449591
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1458507
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5263624
Cellular Component	GO:0005886	plasma membrane	ISO	J:117208
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	IMP	J:176652
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0031982	vesicle	ISO	J:155856
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:182891
Biological Process	GO:0090630	activation of GTPase activity	IGI	J:182891
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0005975	carbohydrate metabolic process	IEA	J:60000
Biological Process	GO:0008643	carbohydrate transport	IEA	J:60000
Biological Process	GO:0071486	cellular response to high light intensity	IMP	J:117208
Biological Process	GO:0032869	cellular response to insulin stimulus	IDA	J:176652
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:73065
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:155856
Biological Process	GO:0006006	glucose metabolic process	IMP	J:117208
Biological Process	GO:0005978	glycogen biosynthetic process	IEA	J:60000
Biological Process	GO:0005977	glycogen metabolic process	IEA	J:60000
Biological Process	GO:0008286	insulin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0008286	insulin receptor signaling pathway	IDA	J:182891
Biological Process	GO:0065002	intracellular protein transmembrane transport	IMP	J:176652
Biological Process	GO:0035556	intracellular signal transduction	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:155856
Biological Process	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	ISO	J:164563
Biological Process	GO:0033119	negative regulation of RNA splicing	ISO	J:155856
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IBA	J:265628
Biological Process	GO:0032287	peripheral nervous system myelin maintenance	IMP	J:160700
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:2000147	positive regulation of cell motility	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0032000	positive regulation of fatty acid beta-oxidation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:155856
Biological Process	GO:0046326	positive regulation of glucose import	ISO	J:164563
Biological Process	GO:0046326	positive regulation of glucose import	IGI	J:176652
Biological Process	GO:0010907	positive regulation of glucose metabolic process	ISO	J:164563
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	ISO	J:164563
Biological Process	GO:0010918	positive regulation of mitochondrial membrane potential	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO	J:155856
Biological Process	GO:0050927	positive regulation of positive chemotaxis	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IDA	J:176652
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	IMP	J:176652
Biological Process	GO:0009967	positive regulation of signal transduction	ISO	J:155856
Biological Process	GO:0010765	positive regulation of sodium ion transport	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0031340	positive regulation of vesicle fusion	IMP	J:176652
Biological Process	GO:0043491	protein kinase B signaling	ISO	J:155856
Biological Process	GO:0072659	protein localization to plasma membrane	IGI	J:176652
Biological Process	GO:0006468	protein phosphorylation	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:176652
Biological Process	GO:0006417	regulation of translation	IEA	J:60000
Biological Process	GO:0032868	response to insulin	ISO	J:155856
Biological Process	GO:0097473	retinal rod cell apoptotic process	IMP	J:117208