GO Annotations Graph

• Symbol: Hes5
• Name: hes family bHLH transcription factor 5
• ID: MGI:104876

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:73065
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:175435
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:155856
Molecular Function	GO:0005515	protein binding	IPI	J:175195
Molecular Function	GO:0005515	protein binding	IPI	J:175435
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2197579
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0048708	astrocyte differentiation	IDA	J:175195
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:139170
Biological Process	GO:0007420	brain development	IMP	J:119796
Biological Process	GO:0043010	camera-type eye development	IMP	J:119796
Biological Process	GO:0051216	cartilage development	IMP	J:175507
Biological Process	GO:0051216	cartilage development	ISO	J:164563
Biological Process	GO:0007155	cell adhesion	IGI	J:94391
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0048469	cell maturation	IGI	J:94391
Biological Process	GO:0022010	central nervous system myelination	IMP	J:119556
Biological Process	GO:0072049	comma-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0021861	forebrain radial glial cell differentiation	ISO	J:155856
Biological Process	GO:0021781	glial cell fate commitment	IMP	J:62537
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0072282	metanephric nephron tubule morphogenesis	IEP	J:93145
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0048712	negative regulation of astrocyte differentiation	IDA	J:82774
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:108846
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	ISO	J:155856
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IMP	J:70081
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:2000981	negative regulation of inner ear receptor cell differentiation	IMP	J:108846
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:160292
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:54662
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:94391
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:160292
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:54662
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:54662
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IDA	J:82774
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IMP	J:119556
Biological Process	GO:2000974	negative regulation of pro-B cell differentiation	ISO	J:155856
Biological Process	GO:2000737	negative regulation of stem cell differentiation	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119556
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119556
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:119556
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0021915	neural tube development	IGI	J:62024
Biological Process	GO:0030182	neuron differentiation	IMP	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:94391
Biological Process	GO:0030182	neuron differentiation	IGI	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:160292
Biological Process	GO:0030182	neuron differentiation	IGI	J:160292
Biological Process	GO:0097150	neuronal stem cell population maintenance	ISO	J:155856
Biological Process	GO:0097150	neuronal stem cell population maintenance	IMP	J:175113
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:97734
Biological Process	GO:0007219	Notch signaling pathway	NAS	J:93145
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:119796
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:218237
Biological Process	GO:0014003	oligodendrocyte development	IMP	J:119556
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:119556
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:119556
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IGI	J:139170
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:108846
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IMP	J:108846
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IDA	J:175195
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:175195
Biological Process	GO:0065003	protein-containing complex assembly	IDA	J:175195
Biological Process	GO:0045595	regulation of cell differentiation	IMP	J:131591
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0031641	regulation of myelination	IMP	J:119556
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:144373
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:144373
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:62024
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:62024
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0072050	S-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:146198
Biological Process	GO:0072086	specification of loop of Henle identity	IEP	J:97734
Biological Process	GO:0021537	telencephalon development	IGI	J:160292
Biological Process	GO:0021537	telencephalon development	IGI	J:139170
Biological Process	GO:0021537	telencephalon development	IGI	J:160292