GO Annotations Graph

• Symbol: Prkar1a
• Name: protein kinase, cAMP dependent regulatory, type I, alpha
• ID: MGI:104878

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030552	cAMP binding	ISO	J:155856
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	ISO	J:164563
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	IMP	J:316520
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	IMP	J:292566
Molecular Function	GO:0004862	cAMP-dependent protein kinase inhibitor activity	IMP	J:331362
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	ISO	J:164563
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	ISO	J:155856
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	IDA	J:177007
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	IMP	J:142482
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	IDA	J:25553
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	IGI	J:78010
Molecular Function	GO:0008603	cAMP-dependent protein kinase regulator activity	IMP	J:78010
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:200504
Molecular Function	GO:0005515	protein binding	IPI	J:52123
Molecular Function	GO:0005515	protein binding	IPI	J:124778
Molecular Function	GO:0005515	protein binding	IPI	J:177007
Molecular Function	GO:0005515	protein binding	IPI	J:265193
Molecular Function	GO:0005515	protein binding	IPI	J:84024
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	ISO	J:164563
Molecular Function	GO:0034236	protein kinase A catalytic subunit binding	IPI	J:265193
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0005930	axoneme	ISO	J:164563
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	ISO	J:155856
Cellular Component	GO:0005952	cAMP-dependent protein kinase complex	IDA	J:177007
Cellular Component	GO:0005813	centrosome	IDA	J:265193
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:177007
Cellular Component	GO:0005737	cytoplasm	TAS	J:39705
Cellular Component	GO:0005737	cytoplasm	IDA	J:265193
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:331263
Cellular Component	GO:0098978	glutamatergic synapse	EXP	J:206458
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:206458
Cellular Component	GO:0001772	immunological synapse	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005771	multivesicular body	IDA	J:177007
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:35122
Cellular Component	GO:0031588	nucleotide-activated protein kinase complex	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0044853	plasma membrane raft	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0097224	sperm connecting piece	IDA	J:265193
Cellular Component	GO:0045202	synapse	IDA	J:206458
Cellular Component	GO:0045202	synapse	EXP	J:206458
Biological Process	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	J:328576
Biological Process	GO:0009887	animal organ morphogenesis	TAS	J:25553
Biological Process	GO:0060038	cardiac muscle cell proliferation	IMP	J:142482
Biological Process	GO:0071377	cellular response to glucagon stimulus	IMP	J:292566
Biological Process	GO:0007507	heart development	IMP	J:142482
Biological Process	GO:0010463	mesenchymal cell proliferation	TAS	J:25553
Biological Process	GO:0001707	mesoderm formation	IMP	J:78010
Biological Process	GO:0046007	negative regulation of activated T cell proliferation	ISO	J:164563
Biological Process	GO:2000480	negative regulation of cAMP-dependent protein kinase activity	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0006469	negative regulation of protein kinase activity	IMP	J:142482
Biological Process	GO:0032024	positive regulation of insulin secretion	IMP	J:328576
Biological Process	GO:0006468	protein phosphorylation	TAS	J:25553
Biological Process	GO:0045859	regulation of protein kinase activity	ISO	J:155856
Biological Process	GO:0045214	sarcomere organization	IMP	J:142482