GO Annotations Graph

• Symbol: Gpx1
• Name: glutathione peroxidase 1
• ID: MGI:104887

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004602	glutathione peroxidase activity	ISO	J:155856
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:41169
Molecular Function	GO:0004602	glutathione peroxidase activity	ISO	J:164563
Molecular Function	GO:0004602	glutathione peroxidase activity	IBA	J:265628
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:113070
Molecular Function	GO:0004602	glutathione peroxidase activity	IDA	J:82905
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:75857
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:44499
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:90710
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:44499
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:90710
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:71506
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:51141
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:44499
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:44499
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:69125
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:71506
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:63988
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:59488
Molecular Function	GO:0004602	glutathione peroxidase activity	IDA	J:81401
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:103116
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:71506
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:113167
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:44499
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:90710
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:115327
Molecular Function	GO:0004602	glutathione peroxidase activity	IMP	J:104667
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0004601	peroxidase activity	IEA	J:60000
Molecular Function	GO:0047066	phospholipid-hydroperoxide glutathione peroxidase activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:122294
Molecular Function	GO:0017124	SH3 domain binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0097413	Lewy body	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:155856
Cellular Component	GO:0005739	mitochondrion	IBA	J:265628
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	HDA	J:86816
Cellular Component	GO:0005739	mitochondrion	IDA	J:39714
Cellular Component	GO:0005739	mitochondrion	HDA	J:151002
Cellular Component	GO:0005739	mitochondrion	IMP	J:62395
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Biological Process	GO:0060055	angiogenesis involved in wound healing	IMP	J:118088
Biological Process	GO:0006915	apoptotic process	IMP	J:112583
Biological Process	GO:0006915	apoptotic process	IMP	J:112582
Biological Process	GO:0019369	arachidonic acid metabolic process	ISO	J:164563
Biological Process	GO:0019369	arachidonic acid metabolic process	IMP	J:41169
Biological Process	GO:0051702	biological process involved in interaction with symbiont	IGI	J:103116
Biological Process	GO:0051702	biological process involved in interaction with symbiont	IGI	J:103116
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:118088
Biological Process	GO:0045454	cell redox homeostasis	ISO	J:164563
Biological Process	GO:0098869	cellular oxidant detoxification	IMP	J:103116
Biological Process	GO:0071333	cellular response to glucose stimulus	ISO	J:155856
Biological Process	GO:0001885	endothelial cell development	IMP	J:118088
Biological Process	GO:0040029	epigenetic regulation of gene expression	ISO	J:164563
Biological Process	GO:0045444	fat cell differentiation	IMP	J:112583
Biological Process	GO:0048144	fibroblast proliferation	IMP	J:87985
Biological Process	GO:0006749	glutathione metabolic process	ISO	J:164563
Biological Process	GO:0006749	glutathione metabolic process	ISO	J:155856
Biological Process	GO:0006749	glutathione metabolic process	IBA	J:265628
Biological Process	GO:0060047	heart contraction	ISO	J:164563
Biological Process	GO:0060047	heart contraction	IMP	J:111478
Biological Process	GO:0042744	hydrogen peroxide catabolic process	ISO	J:155856
Biological Process	GO:0042744	hydrogen peroxide catabolic process	ISO	J:164563
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IBA	J:265628
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IMP	J:51141
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IMP	J:90710
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IMP	J:62395
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IMP	J:115327
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IMP	J:104667
Biological Process	GO:0042744	hydrogen peroxide catabolic process	IMP	J:113167
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:118088
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:72598
Biological Process	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IMP	J:105089
Biological Process	GO:0006629	lipid metabolic process	IMP	J:62395
Biological Process	GO:0019372	lipoxygenase pathway	ISO	J:164563
Biological Process	GO:0045445	myoblast differentiation	IMP	J:112583
Biological Process	GO:0051450	myoblast proliferation	IMP	J:113583
Biological Process	GO:0051450	myoblast proliferation	IMP	J:112583
Biological Process	GO:0014902	myotube differentiation	IMP	J:113583
Biological Process	GO:0014902	myotube differentiation	IMP	J:112583
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO	J:164563
Biological Process	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO	J:164563
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IGI	J:103116
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IGI	J:103116
Biological Process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IMP	J:118088
Biological Process	GO:0090201	negative regulation of release of cytochrome c from mitochondria	ISO	J:164563
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:71798
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IMP	J:105089
Biological Process	GO:0018158	protein oxidation	IMP	J:56648
Biological Process	GO:0033599	regulation of mammary gland epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0061136	regulation of proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:0010332	response to gamma radiation	IGI	J:90710
Biological Process	GO:0010332	response to gamma radiation	IGI	J:90710
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:164563
Biological Process	GO:0042542	response to hydrogen peroxide	IBA	J:265628
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:87985
Biological Process	GO:0042542	response to hydrogen peroxide	IMP	J:118088
Biological Process	GO:0033194	response to hydroperoxide	IMP	J:111894
Biological Process	GO:0006979	response to oxidative stress	IMP	J:111478
Biological Process	GO:0006979	response to oxidative stress	IGI	J:90710
Biological Process	GO:0006979	response to oxidative stress	IMP	J:90710
Biological Process	GO:0006979	response to oxidative stress	IGI	J:90710
Biological Process	GO:0006979	response to oxidative stress	IMP	J:75857
Biological Process	GO:0006979	response to oxidative stress	IMP	J:56648
Biological Process	GO:0006979	response to oxidative stress	IMP	J:115327
Biological Process	GO:0006979	response to oxidative stress	IMP	J:112583
Biological Process	GO:0006979	response to oxidative stress	IMP	J:59142
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:72598
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:115327
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:112583
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:116698
Biological Process	GO:0000302	response to reactive oxygen species	IMP	J:118088
Biological Process	GO:0010269	response to selenium ion	ISO	J:164563
Biological Process	GO:0010269	response to selenium ion	IBA	J:265628
Biological Process	GO:0009609	response to symbiotic bacterium	IGI	J:103116
Biological Process	GO:0009609	response to symbiotic bacterium	IGI	J:103116
Biological Process	GO:0009636	response to toxic substance	IMP	J:59142
Biological Process	GO:0009611	response to wounding	IMP	J:71798
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:115327
Biological Process	GO:0007605	sensory perception of sound	IMP	J:113167
Biological Process	GO:0048741	skeletal muscle fiber development	IMP	J:112583
Biological Process	GO:0043403	skeletal muscle tissue regeneration	IMP	J:112583
Biological Process	GO:0001659	temperature homeostasis	IGI	J:71506
Biological Process	GO:0001659	temperature homeostasis	IGI	J:71506
Biological Process	GO:0006641	triglyceride metabolic process	IMP	J:113070
Biological Process	GO:0009650	UV protection	ISO	J:164563
Biological Process	GO:0042311	vasodilation	IMP	J:111478
Biological Process	GO:0042311	vasodilation	IMP	J:75857