GO Annotations Graph

• Symbol: Ksr1
• Name: kinase suppressor of ras 1
• ID: MGI:105051

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0071889	14-3-3 protein binding	IPI	J:230400
Molecular Function	GO:0071889	14-3-3 protein binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	IMP	J:277858
Molecular Function	GO:0051879	Hsp90 protein binding	IPI	J:230400
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0005078	MAP-kinase scaffold activity	IMP	J:231274
Molecular Function	GO:0005078	MAP-kinase scaffold activity	IMP	J:230400
Molecular Function	GO:0005078	MAP-kinase scaffold activity	IDA	J:150410
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	ISO	J:155856
Molecular Function	GO:0031434	mitogen-activated protein kinase kinase binding	IPI	J:230400
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:326246
Molecular Function	GO:0005515	protein binding	IPI	J:209645
Molecular Function	GO:0005515	protein binding	IPI	J:184683
Molecular Function	GO:0005515	protein binding	IPI	J:192645
Molecular Function	GO:0005515	protein binding	IPI	J:127178
Molecular Function	GO:0005515	protein binding	ISO	J:187529
Molecular Function	GO:0004672	protein kinase activity	IMP	J:277858
Molecular Function	GO:0004672	protein kinase activity	IBA	J:265628
Molecular Function	GO:0019901	protein kinase binding	IPI	J:277858
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:60000
Molecular Function	GO:0004674	protein serine/threonine kinase activity	IEA	J:72245
Molecular Function	GO:0051087	protein-folding chaperone binding	IPI	J:230400
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005783	endoplasmic reticulum	IBA	J:265628
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:187529
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IBA	J:265628
Cellular Component	GO:0016020	membrane	ISO	J:187529
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0032991	protein-containing complex	ISO	J:187529
Biological Process	GO:0019933	cAMP-mediated signaling	IMP	J:231274
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:277858
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:230400
Biological Process	GO:0043410	positive regulation of MAPK cascade	IMP	J:231274
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:150410
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0007265	Ras protein signal transduction	IMP	J:231274
Biological Process	GO:0007265	Ras protein signal transduction	IBA	J:265628
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:84644
Biological Process	GO:0043405	regulation of MAP kinase activity	IMP	J:84644