GO Annotations Graph

• Symbol: Atp2a1
• Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
• ID: MGI:105058

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	ISO	J:155856
Molecular Function	GO:0016887	ATP hydrolysis activity	IEA	J:72247
Molecular Function	GO:0005509	calcium ion binding	ISO	J:164563
Molecular Function	GO:0005509	calcium ion binding	ISO	J:155856
Molecular Function	GO:0005509	calcium ion binding	IDA	J:260257
Molecular Function	GO:0030899	calcium-dependent ATPase activity	ISO	J:155856
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:72247
Molecular Function	GO:0005338	nucleotide-sugar transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005388	P-type calcium transporter activity	ISO	J:164563
Molecular Function	GO:0005388	P-type calcium transporter activity	ISO	J:155856
Molecular Function	GO:0005388	P-type calcium transporter activity	ISO	J:164563
Molecular Function	GO:0005388	P-type calcium transporter activity	IBA	J:265628
Molecular Function	GO:0005388	P-type calcium transporter activity	ISO	J:73065
Molecular Function	GO:0005515	protein binding	IPI	J:274777
Molecular Function	GO:0005515	protein binding	IPI	J:229305
Molecular Function	GO:0005515	protein binding	IPI	J:217579
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0005215	transporter activity	IEA	J:72247
Cellular Component	GO:0005783	endoplasmic reticulum	IEA	J:60000
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ISO	J:164563
Cellular Component	GO:0031673	H zone	ISO	J:164563
Cellular Component	GO:0031674	I band	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016529	sarcoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0016529	sarcoplasmic reticulum	IDA	J:72636
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:229305
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane	IDA	J:217579
Biological Process	GO:0008637	apoptotic mitochondrial changes	ISO	J:164563
Biological Process	GO:0070509	calcium ion import	ISO	J:164563
Biological Process	GO:0070588	calcium ion transmembrane transport	ISO	J:155856
Biological Process	GO:0070588	calcium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:164563
Biological Process	GO:0006816	calcium ion transport	ISO	J:155856
Biological Process	GO:0006816	calcium ion transport	ISO	J:73065
Biological Process	GO:0006874	intracellular calcium ion homeostasis	IBA	J:265628
Biological Process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0051659	maintenance of mitochondrion location	ISO	J:164563
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration	ISO	J:164563
Biological Process	GO:0045988	negative regulation of striated muscle contraction	ISO	J:164563
Biological Process	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	ISO	J:164563
Biological Process	GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	ISO	J:164563
Biological Process	GO:0051561	positive regulation of mitochondrial calcium ion concentration	ISO	J:164563
Biological Process	GO:0006937	regulation of muscle contraction	TAS	J:72636
Biological Process	GO:0006942	regulation of striated muscle contraction	ISO	J:164563
Biological Process	GO:0090076	relaxation of skeletal muscle	ISO	J:164563
Biological Process	GO:0034976	response to endoplasmic reticulum stress	ISO	J:164563
Biological Process	GO:0043434	response to peptide hormone	ISO	J:155856
Biological Process	GO:0070296	sarcoplasmic reticulum calcium ion transport	ISO	J:155856