GO Annotations Graph

• Symbol: Hsd17b1
• Name: hydroxysteroid (17-beta) dehydrogenase 1
• ID: MGI:105077

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0072582	17-beta-hydroxysteroid dehydrogenase (NADP+) activity	IDA	J:48295
Molecular Function	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity	IEA	J:72245
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO	J:164563
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	IDA	J:48295
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	ISO	J:155856
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA	J:265628
Molecular Function	GO:1903924	estradiol binding	ISO	J:164563
Molecular Function	GO:0050661	NADP binding	ISO	J:164563
Molecular Function	GO:0070401	NADP+ binding	ISO	J:164563
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:72247
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0036094	small molecule binding	ISO	J:164563
Molecular Function	GO:0005496	steroid binding	ISO	J:164563
Molecular Function	GO:0047035	testosterone dehydrogenase (NAD+) activity	ISO	J:155856
Molecular Function	GO:0030283	testosterone dehydrogenase [NAD(P)] activity	IDA	J:48295
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Biological Process	GO:0060612	adipose tissue development	IMP	J:253582
Biological Process	GO:0006703	estrogen biosynthetic process	ISO	J:155856
Biological Process	GO:0006703	estrogen biosynthetic process	IDA	J:48295
Biological Process	GO:0006703	estrogen biosynthetic process	ISO	J:164563
Biological Process	GO:0006703	estrogen biosynthetic process	IBA	J:265628
Biological Process	GO:0010467	gene expression	IMP	J:253582
Biological Process	GO:0006629	lipid metabolic process	IMP	J:253582
Biological Process	GO:0007040	lysosome organization	IMP	J:253582
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:253582
Biological Process	GO:0006694	steroid biosynthetic process	IEA	J:60000
Biological Process	GO:0061370	testosterone biosynthetic process	ISO	J:155856
Biological Process	GO:0061370	testosterone biosynthetic process	IDA	J:48295