Slc1a1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Slc1a1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
MGI:105083

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015108	chloride transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0033229	cysteine transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0033229	cysteine transmembrane transporter activity	IDA	J:274779
Molecular Function	GO:0033229	cysteine transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0033229	cysteine transmembrane transporter activity	IDA	J:297338
Molecular Function	GO:0033229	cysteine transmembrane transporter activity	IDA	J:297338
Molecular Function	GO:0140010	D-aspartate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0016595	glutamate binding	ISO	J:155856
Molecular Function	GO:0015501	glutamate:sodium symporter activity	ISO	J:155856
Molecular Function	GO:0015501	glutamate:sodium symporter activity	ISO	J:164563
Molecular Function	GO:0015501	glutamate:sodium symporter activity	IBA	J:265628
Molecular Function	GO:0015501	glutamate:sodium symporter activity	IDA	J:78023
Molecular Function	GO:0005314	high-affinity L-glutamate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	IPI	J:107993
Molecular Function	GO:0015183	L-aspartate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	ISO	J:164563
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	IBA	J:265628
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	IMP	J:87447
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	IDA	J:297525
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	IDA	J:297340
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	ISO	J:297471
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	IDA	J:107993
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005253	monoatomic anion channel activity	IDA	J:297340
Molecular Function	GO:0005515	protein binding	IPI	J:274779
Molecular Function	GO:0005515	protein binding	IPI	J:143132
Molecular Function	GO:0005515	protein binding	IPI	J:310319
Molecular Function	GO:0005515	protein binding	IPI	J:126756
Molecular Function	GO:0005515	protein binding	IPI	J:126756
Molecular Function	GO:0005515	protein binding	IPI	J:200434
Molecular Function	GO:0005515	protein binding	IPI	J:142758
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Molecular Function	GO:0015293	symporter activity	IEA	J:72247
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:229937
Cellular Component	GO:0032279	asymmetric synapse	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0043679	axon terminus	ISO	J:155856
Cellular Component	GO:0071944	cell periphery	ISO	J:155856
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0009986	cell surface	IDA	J:159388
Cellular Component	GO:0009986	cell surface	IDA	J:107993
Cellular Component	GO:0005737	cytoplasm	IDA	J:159388
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IDA	J:184594
Cellular Component	GO:0043198	dendritic shaft	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0150002	distal dendrite	ISO	J:155856
Cellular Component	GO:0031901	early endosome membrane	IDA	J:274779
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:155856
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0097386	glial cell projection	ISO	J:155856
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0016020	membrane	IDA	J:258726
Cellular Component	GO:0045121	membrane raft	IDA	J:297339
Cellular Component	GO:0043005	neuron projection	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	IDA	J:184594
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0099544	perisynaptic space	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:274779
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	J:297342
Cellular Component	GO:0005886	plasma membrane	IDA	J:126756
Cellular Component	GO:0005886	plasma membrane	IDA	J:210853
Cellular Component	GO:0005886	plasma membrane	IDA	J:297340
Cellular Component	GO:0005886	plasma membrane	IDA	J:152978
Cellular Component	GO:0005886	plasma membrane	IPI	J:142758
Cellular Component	GO:0005886	plasma membrane	IDA	J:297340
Cellular Component	GO:0005886	plasma membrane	IDA	J:107993
Cellular Component	GO:0098793	presynapse	ISO	J:155856
Cellular Component	GO:1990635	proximal dendrite	ISO	J:155856
Cellular Component	GO:0055037	recycling endosome	IDA	J:159388
Cellular Component	GO:0055038	recycling endosome membrane	IDA	J:274779
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IMP	J:155750
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	IDA	J:155750
Cellular Component	GO:0045202	synapse	IDA	J:297613
Cellular Component	GO:0043083	synaptic cleft	ISO	J:155856
Cellular Component	GO:0031982	vesicle	IDA	J:152978
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA	J:200434
Biological Process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	J:200434
Biological Process	GO:0032148	activation of protein kinase B activity	IMP	J:297351
Biological Process	GO:0030534	adult behavior	IMP	J:299321
Biological Process	GO:0006865	amino acid transport	IEA	J:60000
Biological Process	GO:0001662	behavioral fear response	IMP	J:192515
Biological Process	GO:0001662	behavioral fear response	IMP	J:297612
Biological Process	GO:0001662	behavioral fear response	IMP	J:192515
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:285023
Biological Process	GO:0007420	brain development	IMP	J:299321
Biological Process	GO:0071242	cellular response to ammonium ion	IMP	J:210853
Biological Process	GO:0071242	cellular response to ammonium ion	IDA	J:210853
Biological Process	GO:1903926	cellular response to bisphenol A	IDA	J:310324
Biological Process	GO:0071314	cellular response to cocaine	IDA	J:299319
Biological Process	GO:0071288	cellular response to mercury ion	IDA	J:298090
Biological Process	GO:0071407	cellular response to organic cyclic compound	ISO	J:297471
Biological Process	GO:0034599	cellular response to oxidative stress	IMP	J:192515
Biological Process	GO:1902476	chloride transmembrane transport	ISO	J:164563
Biological Process	GO:1990708	conditioned place preference	IMP	J:243153
Biological Process	GO:1903712	cysteine transmembrane transport	IDA	J:274779
Biological Process	GO:0042883	cysteine transport	ISO	J:164563
Biological Process	GO:0001816	cytokine production	IMP	J:299321
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IMP	J:299321
Biological Process	GO:0070779	D-aspartate import across plasma membrane	ISO	J:164563
Biological Process	GO:0070777	D-aspartate transport	ISO	J:164563
Biological Process	GO:0042417	dopamine metabolic process	IMP	J:242284
Biological Process	GO:0007212	dopamine receptor signaling pathway	IMP	J:256530
Biological Process	GO:0007212	dopamine receptor signaling pathway	IMP	J:242284
Biological Process	GO:0045184	establishment of protein localization	IMP	J:155750
Biological Process	GO:0010467	gene expression	IMP	J:242284
Biological Process	GO:0007215	glutamate receptor signaling pathway	IMP	J:256530
Biological Process	GO:0006750	glutathione biosynthetic process	IDA	J:297338
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:299321
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:192515
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:192515
Biological Process	GO:0006749	glutathione metabolic process	IMP	J:142758
Biological Process	GO:0007625	grooming behavior	IMP	J:242284
Biological Process	GO:0060047	heart contraction	IMP	J:213330
Biological Process	GO:0090461	intracellular glutamate homeostasis	IMP	J:155750
Biological Process	GO:0006882	intracellular zinc ion homeostasis	IMP	J:297350
Biological Process	GO:0006882	intracellular zinc ion homeostasis	IMP	J:166444
Biological Process	GO:0140009	L-aspartate import across plasma membrane	ISO	J:164563
Biological Process	GO:0070778	L-aspartate transmembrane transport	ISO	J:164563
Biological Process	GO:0051938	L-glutamate import	ISO	J:164563
Biological Process	GO:0098712	L-glutamate import across plasma membrane	ISO	J:164563
Biological Process	GO:0098712	L-glutamate import across plasma membrane	IDA	J:200434
Biological Process	GO:0098712	L-glutamate import across plasma membrane	IMP	J:96918
Biological Process	GO:0098712	L-glutamate import across plasma membrane	IMP	J:200434
Biological Process	GO:0098712	L-glutamate import across plasma membrane	IDA	J:297525
Biological Process	GO:0098712	L-glutamate import across plasma membrane	IMP	J:155496
Biological Process	GO:0015813	L-glutamate transmembrane transport	ISO	J:164563
Biological Process	GO:0015813	L-glutamate transmembrane transport	ISO	J:155856
Biological Process	GO:0015813	L-glutamate transmembrane transport	IBA	J:265628
Biological Process	GO:0015813	L-glutamate transmembrane transport	IDA	J:107993
Biological Process	GO:0007611	learning or memory	IMP	J:297612
Biological Process	GO:0007611	learning or memory	IMP	J:212923
Biological Process	GO:0007626	locomotory behavior	IMP	J:242284
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:155750
Biological Process	GO:0060291	long-term synaptic potentiation	IMP	J:256530
Biological Process	GO:0035633	maintenance of blood-brain barrier	IMP	J:285023
Biological Process	GO:0007613	memory	IMP	J:299321
Biological Process	GO:0061744	motor behavior	IMP	J:299321
Biological Process	GO:0061744	motor behavior	IMP	J:256530
Biological Process	GO:0097049	motor neuron apoptotic process	IDA	J:200434
Biological Process	GO:0097049	motor neuron apoptotic process	IMP	J:200434
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:262753
Biological Process	GO:0022008	neurogenesis	IMP	J:262753
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:299467
Biological Process	GO:0036475	neuron death in response to oxidative stress	IMP	J:285023
Biological Process	GO:0098877	neurotransmitter receptor transport to plasma membrane	IMP	J:212923
Biological Process	GO:0098877	neurotransmitter receptor transport to plasma membrane	IMP	J:210853
Biological Process	GO:0018105	peptidyl-serine phosphorylation	IMP	J:210853
Biological Process	GO:0010460	positive regulation of heart rate	IMP	J:213330
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IDA	J:155750
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	IMP	J:155750
Biological Process	GO:0002027	regulation of heart rate	IMP	J:213330
Biological Process	GO:0001932	regulation of protein phosphorylation	IMP	J:210853
Biological Process	GO:0090313	regulation of protein targeting to membrane	IMP	J:210853
Biological Process	GO:0001975	response to amphetamine	IMP	J:242284
Biological Process	GO:0072347	response to anesthetic	IMP	J:212923
Biological Process	GO:0072347	response to anesthetic	IMP	J:297612
Biological Process	GO:0072347	response to anesthetic	IMP	J:297351
Biological Process	GO:0048678	response to axon injury	IMP	J:299467
Biological Process	GO:0048678	response to axon injury	IMP	J:297351
Biological Process	GO:0048678	response to axon injury	IDA	J:200434
Biological Process	GO:0048678	response to axon injury	IMP	J:200434
Biological Process	GO:0048678	response to axon injury	IMP	J:297350
Biological Process	GO:0036293	response to decreased oxygen levels	IMP	J:285023
Biological Process	GO:0036293	response to decreased oxygen levels	IMP	J:262753
Biological Process	GO:0043278	response to morphine	IMP	J:243153
Biological Process	GO:0043278	response to morphine	IDA	J:243153
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:297352
Biological Process	GO:0009410	response to xenobiotic stimulus	IMP	J:170196
Biological Process	GO:0060041	retina development in camera-type eye	IMP	J:299320
Biological Process	GO:0010842	retina layer formation	IMP	J:155496
Biological Process	GO:0010842	retina layer formation	IMP	J:261769
Biological Process	GO:0060013	righting reflex	IMP	J:170196
Biological Process	GO:0006801	superoxide metabolic process	IMP	J:299467
Biological Process	GO:0050808	synapse organization	IMP	J:299321
Biological Process	GO:0071577	zinc ion transmembrane transport	IMP	J:299467

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