GO Annotations Graph

• Symbol: Slc6a5
• Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5
• ID: MGI:105090

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015187	glycine transmembrane transporter activity	ISO	J:155856
Molecular Function	GO:0015375	glycine:sodium symporter activity	ISO	J:155856
Molecular Function	GO:0015375	glycine:sodium symporter activity	ISO	J:164563
Molecular Function	GO:0015375	glycine:sodium symporter activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0015293	symporter activity	IEA	J:60000
Cellular Component	GO:0031045	dense core granule	ISO	J:155856
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0098690	glycinergic synapse	ISO	J:155856
Cellular Component	GO:0098690	glycinergic synapse	IDA	J:86625
Cellular Component	GO:0098690	glycinergic synapse	IDA	J:86625
Cellular Component	GO:0098690	glycinergic synapse	IMP	J:86625
Cellular Component	GO:0098690	glycinergic synapse	IDA	J:86625
Cellular Component	GO:0098690	glycinergic synapse	IDA	J:86625
Cellular Component	GO:0098690	glycinergic synapse	IMP	J:86625
Cellular Component	GO:0098690	glycinergic synapse	EXP	J:244085
Cellular Component	GO:0098690	glycinergic synapse	IDA	J:244085
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0042734	presynaptic membrane	ISO	J:155856
Biological Process	GO:1903804	glycine import across plasma membrane	ISO	J:164563
Biological Process	GO:1903804	glycine import across plasma membrane	IBA	J:265628
Biological Process	GO:0015816	glycine transport	ISO	J:155856
Biological Process	GO:0098810	neurotransmitter reuptake	EXP	J:244085
Biological Process	GO:0098810	neurotransmitter reuptake	IDA	J:244085
Biological Process	GO:0006836	neurotransmitter transport	IEA	J:60000
Biological Process	GO:0001504	neurotransmitter uptake	IDA	J:86625
Biological Process	GO:0001504	neurotransmitter uptake	IMP	J:86625
Biological Process	GO:0001504	neurotransmitter uptake	IDA	J:86625
Biological Process	GO:0001504	neurotransmitter uptake	IMP	J:86625
Biological Process	GO:0001504	neurotransmitter uptake	IDA	J:86625
Biological Process	GO:0001504	neurotransmitter uptake	IDA	J:86625
Biological Process	GO:0035725	sodium ion transmembrane transport	IBA	J:265628
Biological Process	GO:0060012	synaptic transmission, glycinergic	ISO	J:164563
Biological Process	GO:0060012	synaptic transmission, glycinergic	IBA	J:265628