GO Annotations Graph

• Symbol: Ube3a
• Name: ubiquitin protein ligase E3A
• ID: MGI:105098

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:41090
Molecular Function	GO:0005515	protein binding	IPI	J:105872
Molecular Function	GO:0003713	transcription coactivator activity	IDA	J:105872
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IBA	J:265628
Molecular Function	GO:0061630	ubiquitin protein ligase activity	IDA	J:41090
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0005829	cytosol	IDA	J:41090
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:224839
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:224839
Cellular Component	GO:0005634	nucleus	IDA	J:41090
Cellular Component	GO:0000502	proteasome complex	IEA	J:60000
Biological Process	GO:0030521	androgen receptor signaling pathway	IPI	J:105872
Biological Process	GO:0035641	locomotory exploration behavior	ISO	J:155856
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IDA	J:224839
Biological Process	GO:0050804	modulation of chemical synaptic transmission	IMP	J:224839
Biological Process	GO:0061743	motor learning	ISO	J:155856
Biological Process	GO:0061002	negative regulation of dendritic spine morphogenesis	ISO	J:155856
Biological Process	GO:0001541	ovarian follicle development	IMP	J:99980
Biological Process	GO:1905528	positive regulation of Golgi lumen acidification	ISO	J:155856
Biological Process	GO:1905528	positive regulation of Golgi lumen acidification	IMP	J:196065
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IMP	J:105872
Biological Process	GO:0031398	positive regulation of protein ubiquitination	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:105872
Biological Process	GO:0050847	progesterone receptor signaling pathway	ISO	J:164563
Biological Process	GO:0060736	prostate gland growth	IMP	J:99980
Biological Process	GO:0060736	prostate gland growth	IMP	J:105872
Biological Process	GO:0051865	protein autoubiquitination	ISO	J:164563
Biological Process	GO:0070936	protein K48-linked ubiquitination	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	IBA	J:265628
Biological Process	GO:0016567	protein ubiquitination	IDA	J:41090
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:215947
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	IBA	J:265628
Biological Process	GO:0032570	response to progesterone	ISO	J:164563
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0035037	sperm entry	IMP	J:99980
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process	IDA	J:105872