GO Annotations Graph

• Symbol: Hpx
• Name: hemopexin
• ID: MGI:105112

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0020037	heme binding	ISO	J:73065
Molecular Function	GO:0015232	heme transmembrane transporter activity	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:73065
Biological Process	GO:0042168	heme metabolic process	IBA	J:265628
Biological Process	GO:0042168	heme metabolic process	IMP	J:137368
Biological Process	GO:0015886	heme transport	IEA	J:72247
Biological Process	GO:0020027	hemoglobin metabolic process	IMP	J:58821
Biological Process	GO:0006879	intracellular iron ion homeostasis	IEA	J:72247
Biological Process	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP	J:139247
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IMP	J:139247
Biological Process	GO:0060332	positive regulation of response to type II interferon	IMP	J:139247
Biological Process	GO:0060335	positive regulation of type II interferon-mediated signaling pathway	IMP	J:139247
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP	J:139247
Biological Process	GO:0051246	regulation of protein metabolic process	IMP	J:58821
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	IMP	J:139247
Biological Process	GO:0007260	tyrosine phosphorylation of STAT protein	IMP	J:139247