GO Annotations Graph

• Symbol: Cxcr2
• Name: C-X-C motif chemokine receptor 2
• ID: MGI:105303

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016494	C-X-C chemokine receptor activity	ISO	J:164563
Molecular Function	GO:0004950	chemokine receptor activity	TAS	J:80798
Molecular Function	GO:0004950	chemokine receptor activity	IDA	J:108306
Molecular Function	GO:0004930	G protein-coupled receptor activity	ISO	J:164563
Molecular Function	GO:0019959	interleukin-8 binding	ISO	J:164563
Molecular Function	GO:0004918	interleukin-8 receptor activity	ISO	J:164563
Molecular Function	GO:0004918	interleukin-8 receptor activity	TAS	J:32263
Molecular Function	GO:0005515	protein binding	IPI	J:88000
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0042629	mast cell granule	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0015630	microtubule cytoskeleton	ISO	J:164563
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	ISO	J:155856
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006968	cellular defense response	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	ISO	J:164563
Biological Process	GO:0006935	chemotaxis	TAS	J:80798
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:60000
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	IEA	J:72247
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0038112	interleukin-8-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0072173	metanephric tubule morphogenesis	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:108306
Biological Process	GO:0033030	negative regulation of neutrophil apoptotic process	ISO	J:155856
Biological Process	GO:0042119	neutrophil activation	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:164563
Biological Process	GO:0030593	neutrophil chemotaxis	ISO	J:155856
Biological Process	GO:0030593	neutrophil chemotaxis	IBA	J:265628
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:155856
Biological Process	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:0002690	positive regulation of leukocyte chemotaxis	ISO	J:155856
Biological Process	GO:0090023	positive regulation of neutrophil chemotaxis	ISO	J:155856
Biological Process	GO:0043117	positive regulation of vascular permeability	ISO	J:155856
Biological Process	GO:0031623	receptor internalization	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000