GO Annotations Graph

• Symbol: Il6ra
• Name: interleukin 6 receptor, alpha
• ID: MGI:105304

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0070119	ciliary neurotrophic factor binding	ISO	J:164563
Molecular Function	GO:0004897	ciliary neurotrophic factor receptor activity	ISO	J:164563
Molecular Function	GO:0004896	cytokine receptor activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019970	interleukin-11 binding	IBA	J:265628
Molecular Function	GO:0004921	interleukin-11 receptor activity	IBA	J:265628
Molecular Function	GO:0019981	interleukin-6 binding	ISO	J:164563
Molecular Function	GO:0019981	interleukin-6 binding	IBA	J:265628
Molecular Function	GO:0004915	interleukin-6 receptor activity	ISO	J:164563
Molecular Function	GO:0004915	interleukin-6 receptor activity	IDA	J:260609
Molecular Function	GO:0005138	interleukin-6 receptor binding	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:164563
Cellular Component	GO:0070110	ciliary neurotrophic factor receptor complex	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005896	interleukin-6 receptor complex	ISO	J:164563
Cellular Component	GO:0005896	interleukin-6 receptor complex	IDA	J:260609
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0032809	neuronal cell body membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9634444
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Biological Process	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0019221	cytokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048589	developmental growth	ISO	J:155856
Biological Process	GO:0031018	endocrine pancreas development	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:260609
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0070102	interleukin-6-mediated signaling pathway	IDA	J:1806
Biological Process	GO:0032966	negative regulation of collagen biosynthetic process	ISO	J:164563
Biological Process	GO:0010536	positive regulation of activation of Janus kinase activity	ISO	J:164563
Biological Process	GO:0010536	positive regulation of activation of Janus kinase activity	IBA	J:265628
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0032722	positive regulation of chemokine production	ISO	J:164563
Biological Process	GO:0072126	positive regulation of glomerular mesangial cell proliferation	ISO	J:164563
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:1901731	positive regulation of platelet aggregation	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	ISO	J:164563
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IBA	J:265628
Biological Process	GO:0034097	response to cytokine	ISO	J:164563
Biological Process	GO:0072540	T-helper 17 cell lineage commitment	IDA	J:260609
Biological Process	GO:0010573	vascular endothelial growth factor production	ISO	J:164563