GO Annotations Graph

• Symbol: Il4ra
• Name: interleukin 4 receptor, alpha
• ID: MGI:105367

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004896	cytokine receptor activity	IBA	J:265628
Molecular Function	GO:0004913	interleukin-4 receptor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:113957
Cellular Component	GO:0034451	centriolar satellite	ISO	J:164563
Cellular Component	GO:0009897	external side of plasma membrane	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0042832	defense response to protozoan	IMP	J:20463
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0016064	immunoglobulin mediated immune response	IMP	J:100883
Biological Process	GO:0035771	interleukin-4-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0045626	negative regulation of T-helper 1 cell differentiation	IGI	J:126429
Biological Process	GO:0032722	positive regulation of chemokine production	IMP	J:157197
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:214452
Biological Process	GO:0002639	positive regulation of immunoglobulin production	IMP	J:100883
Biological Process	GO:0043032	positive regulation of macrophage activation	IMP	J:157197
Biological Process	GO:0043306	positive regulation of mast cell degranulation	IMP	J:100883
Biological Process	GO:1901741	positive regulation of myoblast fusion	IMP	J:107688
Biological Process	GO:0045630	positive regulation of T-helper 2 cell differentiation	IGI	J:126429
Biological Process	GO:0002532	production of molecular mediator involved in inflammatory response	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0045063	T-helper 1 cell differentiation	IGI	J:126429
Biological Process	GO:0045064	T-helper 2 cell differentiation	IGI	J:126429