Ptch1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ptch1
patched 1
MGI:105373

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0015485	cholesterol binding	TAS	J:113791
Molecular Function	GO:0015485	cholesterol binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	ISO	J:164563
Molecular Function	GO:0030332	cyclin binding	IPI	J:180492
Molecular Function	GO:0097108	hedgehog family protein binding	ISO	J:164563
Molecular Function	GO:0097108	hedgehog family protein binding	IBA	J:265628
Molecular Function	GO:0008158	hedgehog receptor activity	IBA	J:265628
Molecular Function	GO:0008158	hedgehog receptor activity	TAS	J:72380
Molecular Function	GO:0008201	heparin binding	IDA	J:113791
Molecular Function	GO:0005113	patched binding	IDA	J:113791
Molecular Function	GO:0005515	protein binding	IPI	J:113791
Molecular Function	GO:0005515	protein binding	IPI	J:200497
Molecular Function	GO:0005515	protein binding	IPI	J:118622
Molecular Function	GO:0005515	protein binding	IPI	J:251210
Molecular Function	GO:0005515	protein binding	IPI	J:226676
Molecular Function	GO:0005515	protein binding	IPI	J:201190
Molecular Function	GO:0044877	protein-containing complex binding	IDA	J:180492
Molecular Function	GO:0005119	smoothened binding	ISO	J:164563
Molecular Function	GO:0005119	smoothened binding	IBA	J:265628
Molecular Function	GO:0008270	zinc ion binding	NAS	J:113791
Cellular Component	GO:0045177	apical part of cell	ISO	J:164563
Cellular Component	GO:0044295	axonal growth cone	ISO	J:155856
Cellular Component	GO:0005901	caveola	ISO	J:164563
Cellular Component	GO:0005929	cilium	IDA	J:151923
Cellular Component	GO:0005929	cilium	IDA	J:153142
Cellular Component	GO:0044294	dendritic growth cone	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	TAS	J:113791
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0030496	midbody	IDA	J:169791
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:180534
Cellular Component	GO:0005886	plasma membrane	IDA	J:180492
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5632642
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5632644
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5632654
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-517521
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0005886	plasma membrane	TAS	J:72380
Cellular Component	GO:0005886	plasma membrane	IDA	J:201190
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:85472
Biological Process	GO:0007420	brain development	IMP	J:175111
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IMP	J:154102
Biological Process	GO:0061005	cell differentiation involved in kidney development	IGI	J:154102
Biological Process	GO:0001709	cell fate determination	IGI	J:210838
Biological Process	GO:0072203	cell proliferation involved in metanephros development	IMP	J:154102
Biological Process	GO:0071397	cellular response to cholesterol	ISO	J:164563
Biological Process	GO:0071397	cellular response to cholesterol	IEP	J:180534
Biological Process	GO:0071679	commissural neuron axon guidance	ISO	J:155856
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0021904	dorsal/ventral neural tube patterning	IMP	J:42441
Biological Process	GO:0009953	dorsal/ventral pattern formation	IGI	J:94269
Biological Process	GO:0030326	embryonic limb morphogenesis	IGI	J:69771
Biological Process	GO:0030326	embryonic limb morphogenesis	IMP	J:72380
Biological Process	GO:0048568	embryonic organ development	IGI	J:205269
Biological Process	GO:0009957	epidermal cell fate specification	IGI	J:210838
Biological Process	GO:0008544	epidermis development	IMP	J:124280
Biological Process	GO:0050673	epithelial cell proliferation	IMP	J:124280
Biological Process	GO:0042593	glucose homeostasis	IMP	J:65293
Biological Process	GO:0003007	heart morphogenesis	IMP	J:42441
Biological Process	GO:0035137	hindlimb morphogenesis	IMP	J:42441
Biological Process	GO:0001701	in utero embryonic development	IGI	J:182970
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:124280
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:124280
Biological Process	GO:0035108	limb morphogenesis	ISO	J:164563
Biological Process	GO:0030879	mammary gland development	IMP	J:42408
Biological Process	GO:0030879	mammary gland development	IMP	J:42408
Biological Process	GO:0060603	mammary gland duct morphogenesis	IMP	J:42408
Biological Process	GO:0060644	mammary gland epithelial cell differentiation	IMP	J:42408
Biological Process	GO:0051782	negative regulation of cell division	IMP	J:180492
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:180492
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:106653
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:219044
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	IMP	J:124280
Biological Process	GO:0010839	negative regulation of keratinocyte proliferation	IMP	J:124280
Biological Process	GO:0040015	negative regulation of multicellular organism growth	IMP	J:72380
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:180534
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	NAS	J:175111
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IBA	J:265628
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IDA	J:69847
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:72380
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:92058
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IDA	J:38383
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:151923
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IGI	J:142506
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	IMP	J:154102
Biological Process	GO:2000647	negative regulation of stem cell proliferation	IMP	J:124280
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0021997	neural plate axis specification	IMP	J:175111
Biological Process	GO:0001843	neural tube closure	IMP	J:42441
Biological Process	GO:0001841	neural tube formation	IDA	J:113791
Biological Process	GO:0021532	neural tube patterning	ISO	J:164563
Biological Process	GO:0007389	pattern specification process	IMP	J:42441
Biological Process	GO:0060037	pharyngeal system development	ISO	J:164563
Biological Process	GO:0010875	positive regulation of cholesterol efflux	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:219044
Biological Process	GO:0045606	positive regulation of epidermal cell differentiation	IGI	J:210838
Biological Process	GO:0072659	protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0016485	protein processing	IMP	J:100466
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:154102
Biological Process	GO:0040008	regulation of growth	IMP	J:42441
Biological Process	GO:0007346	regulation of mitotic cell cycle	IMP	J:106653
Biological Process	GO:0032880	regulation of protein localization	IDA	J:180492
Biological Process	GO:0032880	regulation of protein localization	IMP	J:106653
Biological Process	GO:0010157	response to chlorate	IDA	J:71184
Biological Process	GO:0007165	signal transduction	IDA	J:113791
Biological Process	GO:0061053	somite development	ISO	J:164563
Biological Process	GO:0061053	somite development	IMP	J:175111
Biological Process	GO:0021522	spinal cord motor neuron differentiation	IGI	J:188764
Biological Process	GO:0072089	stem cell proliferation	IMP	J:124280
Biological Process	GO:0072089	stem cell proliferation	IMP	J:124280

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24