GO Annotations Graph

• Symbol: Il18r1
• Name: interleukin 18 receptor 1
• ID: MGI:105383

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042007	interleukin-18 binding	ISO	J:164563
Molecular Function	GO:0042007	interleukin-18 binding	IBA	J:265628
Molecular Function	GO:0042008	interleukin-18 receptor activity	ISO	J:164563
Molecular Function	GO:0042008	interleukin-18 receptor activity	IBA	J:265628
Molecular Function	GO:0042008	interleukin-18 receptor activity	IMP	J:70298
Molecular Function	GO:0050135	NAD(P)+ nucleosidase activity	IEA	J:72245
Molecular Function	GO:0061809	NAD+ nucleotidase, cyclic ADP-ribose generating	IEA	J:72245
Molecular Function	GO:0005515	protein binding	IPI	J:224865
Cellular Component	GO:0045092	interleukin-18 receptor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Biological Process	GO:0006954	inflammatory response	IEA	J:60000
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IBA	J:265628
Biological Process	GO:0035655	interleukin-18-mediated signaling pathway	IMP	J:70298
Biological Process	GO:0030101	natural killer cell activation	IMP	J:70298
Biological Process	GO:0120163	negative regulation of cold-induced thermogenesis	IMP	J:249916
Biological Process	GO:0038061	NIK/NF-kappaB signaling	IMP	J:70298
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	IMP	J:70298
Biological Process	GO:2000556	positive regulation of T-helper 1 cell cytokine production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	ISO	J:164563
Biological Process	GO:0032729	positive regulation of type II interferon production	IBA	J:265628
Biological Process	GO:0032729	positive regulation of type II interferon production	IMP	J:70298
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0045063	T-helper 1 cell differentiation	IMP	J:70298
Biological Process	GO:0032609	type II interferon production	IMP	J:70298