GO Annotations Graph

• Symbol: Vegfb
• Name: vascular endothelial growth factor B
• ID: MGI:106199

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042056	chemoattractant activity	ISO	J:164563
Molecular Function	GO:0042056	chemoattractant activity	IBA	J:265628
Molecular Function	GO:0008083	growth factor activity	IBA	J:265628
Molecular Function	GO:0008201	heparin binding	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	IPI	J:34817
Molecular Function	GO:0005515	protein binding	IPI	J:34817
Molecular Function	GO:0043183	vascular endothelial growth factor receptor 1 binding	ISO	J:164563
Molecular Function	GO:0043183	vascular endothelial growth factor receptor 1 binding	IBA	J:265628
Cellular Component	GO:0005576	extracellular region	IDA	J:34817
Cellular Component	GO:0005615	extracellular space	ISO	J:164563
Cellular Component	GO:0005615	extracellular space	IBA	J:265628
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:34817
Cellular Component	GO:0016020	membrane	IEA	J:72247
Biological Process	GO:0001525	angiogenesis	IEA	J:60000
Biological Process	GO:0060048	cardiac muscle contraction	IMP	J:60503
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0060976	coronary vasculature development	IMP	J:60503
Biological Process	GO:0007507	heart development	IMP	J:60503
Biological Process	GO:0050930	induction of positive chemotaxis	ISO	J:164563
Biological Process	GO:0050930	induction of positive chemotaxis	IBA	J:265628
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IBA	J:265628
Biological Process	GO:0051781	positive regulation of cell division	IEA	J:60000
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0060754	positive regulation of mast cell chemotaxis	ISO	J:164563
Biological Process	GO:0060754	positive regulation of mast cell chemotaxis	IBA	J:265628
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IBA	J:265628
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0035470	positive regulation of vascular wound healing	ISO	J:164563
Biological Process	GO:0006493	protein O-linked glycosylation	IDA	J:34817
Biological Process	GO:0001666	response to hypoxia	IBA	J:265628
Biological Process	GO:0002040	sprouting angiogenesis	IBA	J:265628
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0038084	vascular endothelial growth factor signaling pathway	IBA	J:265628