GO Annotations Graph

• Symbol: Spink1
• Name: serine peptidase inhibitor, Kazal type 1
• ID: MGI:106202

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0030414	peptidase inhibitor activity	IDA	J:25070
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	ISO	J:155856
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IMP	J:159257
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IDA	J:145646
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	IDA	J:185331
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005576	extracellular region	IEA	J:60000
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:145646
Biological Process	GO:0090281	negative regulation of calcium ion import	IDA	J:52103
Biological Process	GO:0090281	negative regulation of calcium ion import	IDA	J:185331
Biological Process	GO:0010751	negative regulation of nitric oxide mediated signal transduction	IDA	J:185331
Biological Process	GO:0010466	negative regulation of peptidase activity	IDA	J:25070
Biological Process	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation	IDA	J:185331
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	IMP	J:159257
Biological Process	GO:1900004	negative regulation of serine-type endopeptidase activity	IDA	J:185331
Biological Process	GO:0007263	nitric oxide mediated signal transduction	IDA	J:185331
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:185331
Biological Process	GO:0060046	regulation of acrosome reaction	IDA	J:185331
Biological Process	GO:2001256	regulation of store-operated calcium entry	IDA	J:185331
Biological Process	GO:0048240	sperm capacitation	IDA	J:185331