Nrp1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Nrp1
neuropilin 1
MGI:106206

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IPI	J:63336
Molecular Function	GO:0019838	growth factor binding	IPI	J:63336
Molecular Function	GO:0005096	GTPase activator activity	ISO	J:164563
Molecular Function	GO:0008201	heparin binding	IEA	J:60000
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:226761
Molecular Function	GO:0005515	protein binding	IPI	J:183995
Molecular Function	GO:0005515	protein binding	IPI	J:214295
Molecular Function	GO:0005515	protein binding	IPI	J:136695
Molecular Function	GO:0005515	protein binding	IPI	J:144697
Molecular Function	GO:0005515	protein binding	IPI	J:245348
Molecular Function	GO:0005515	protein binding	IPI	J:137627
Molecular Function	GO:0005515	protein binding	IPI	J:91658
Molecular Function	GO:0005515	protein binding	IPI	J:99780
Molecular Function	GO:0005515	protein binding	IPI	J:91658
Molecular Function	GO:0005515	protein binding	IPI	J:57968
Molecular Function	GO:0019901	protein kinase binding	IPI	J:191610
Molecular Function	GO:0019901	protein kinase binding	IPI	J:191610
Molecular Function	GO:0017154	semaphorin receptor activity	ISO	J:155856
Molecular Function	GO:0017154	semaphorin receptor activity	IBA	J:265628
Molecular Function	GO:0017154	semaphorin receptor activity	IGI	J:82114
Molecular Function	GO:0017154	semaphorin receptor activity	IDA	J:91658
Molecular Function	GO:0017154	semaphorin receptor activity	IPI	J:91658
Molecular Function	GO:0038085	vascular endothelial growth factor binding	ISO	J:164563
Molecular Function	GO:0038085	vascular endothelial growth factor binding	IPI	J:208348
Molecular Function	GO:0038085	vascular endothelial growth factor binding	IBA	J:265628
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	IMP	J:174966
Molecular Function	GO:0005021	vascular endothelial growth factor receptor activity	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:174966
Cellular Component	GO:0030424	axon	IDA	J:175836
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0030424	axon	IBA	J:265628
Cellular Component	GO:0030424	axon	IDA	J:96969
Cellular Component	GO:0009986	cell surface	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005769	early endosome	IDA	J:197143
Cellular Component	GO:0005925	focal adhesion	IDA	J:214295
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:106639
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:106639
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:106639
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:106639
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:106639
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:106639
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0005739	mitochondrion	IEA	J:60000
Cellular Component	GO:0005883	neurofilament	IDA	J:98330
Cellular Component	GO:0043005	neuron projection	IDA	J:191610
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	IDA	J:197143
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421140
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421142
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421143
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421144
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-421148
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-445078
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-9010950
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-421136
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-421138
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-NUL-421139
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:106639
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:106639
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:106639
Cellular Component	GO:0097443	sorting endosome	IDA	J:197143
Biological Process	GO:0031532	actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:208348
Biological Process	GO:0001525	angiogenesis	IGI	J:197143
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IMP	J:93809
Biological Process	GO:0001525	angiogenesis	IMP	J:93799
Biological Process	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	IMP	J:208348
Biological Process	GO:0009887	animal organ morphogenesis	IEA	J:72247
Biological Process	GO:0048844	artery morphogenesis	IMP	J:208348
Biological Process	GO:0048844	artery morphogenesis	IMP	J:197143
Biological Process	GO:0048675	axon extension	IGI	J:93799
Biological Process	GO:0048675	axon extension	IGI	J:93799
Biological Process	GO:0048846	axon extension involved in axon guidance	IMP	J:187616
Biological Process	GO:0048846	axon extension involved in axon guidance	IDA	J:49908
Biological Process	GO:0048846	axon extension involved in axon guidance	IDA	J:49908
Biological Process	GO:0007411	axon guidance	IBA	J:265628
Biological Process	GO:0007411	axon guidance	IMP	J:93799
Biological Process	GO:0007411	axon guidance	IMP	J:93799
Biological Process	GO:0007411	axon guidance	IMP	J:95356
Biological Process	GO:0007411	axon guidance	IMP	J:93799
Biological Process	GO:0007411	axon guidance	IMP	J:93799
Biological Process	GO:0007411	axon guidance	IDA	J:98330
Biological Process	GO:0007411	axon guidance	IMP	J:98330
Biological Process	GO:0007411	axon guidance	IMP	J:93799
Biological Process	GO:0007413	axonal fasciculation	IMP	J:121420
Biological Process	GO:0060385	axonogenesis involved in innervation	IMP	J:187616
Biological Process	GO:0150020	basal dendrite arborization	IGI	J:191610
Biological Process	GO:0150018	basal dendrite development	IMP	J:191610
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:93809
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:93809
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:195430
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:176047
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:208348
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:121420
Biological Process	GO:0021785	branchiomotor neuron axon guidance	IMP	J:142715
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0060980	cell migration involved in coronary vasculogenesis	IC	J:208348
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	IC	J:208348
Biological Process	GO:0002042	cell migration involved in sprouting angiogenesis	IMP	J:195430
Biological Process	GO:0035729	cellular response to hepatocyte growth factor stimulus	ISO	J:164563
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	IMP	J:208348
Biological Process	GO:0071679	commissural neuron axon guidance	IMP	J:174966
Biological Process	GO:0060982	coronary artery morphogenesis	IMP	J:197143
Biological Process	GO:0016358	dendrite development	IMP	J:93799
Biological Process	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	IMP	J:124081
Biological Process	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	IGI	J:124081
Biological Process	GO:1904835	dorsal root ganglion morphogenesis	IMP	J:149474
Biological Process	GO:0035767	endothelial cell chemotaxis	ISO	J:164563
Biological Process	GO:0043542	endothelial cell migration	ISO	J:164563
Biological Process	GO:0043542	endothelial cell migration	IMP	J:214295
Biological Process	GO:0021612	facial nerve structural organization	IMP	J:142715
Biological Process	GO:0021612	facial nerve structural organization	IMP	J:134486
Biological Process	GO:1903375	facioacoustic ganglion development	IMP	J:134486
Biological Process	GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus	IMP	J:166892
Biological Process	GO:0007507	heart development	IGI	J:93799
Biological Process	GO:0048012	hepatocyte growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007229	integrin-mediated signaling pathway	IMP	J:214295
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:142715
Biological Process	GO:0097475	motor neuron migration	IMP	J:226761
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030517	negative regulation of axon extension	IGI	J:93799
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	ISO	J:155856
Biological Process	GO:0048843	negative regulation of axon extension involved in axon guidance	IDA	J:49908
Biological Process	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	IMP	J:175836
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:175836
Biological Process	GO:0021675	nerve development	IMP	J:187616
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0001755	neural crest cell migration	IBA	J:265628
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	IMP	J:209482
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	IMP	J:134486
Biological Process	GO:1901166	neural crest cell migration involved in autonomic nervous system development	IMP	J:149474
Biological Process	GO:0048666	neuron development	IMP	J:175836
Biological Process	GO:0001764	neuron migration	IMP	J:187616
Biological Process	GO:0038189	neuropilin signaling pathway	IMP	J:228701
Biological Process	GO:0038189	neuropilin signaling pathway	ISO	J:164563
Biological Process	GO:0038189	neuropilin signaling pathway	IMP	J:214295
Biological Process	GO:1905040	otic placode development	IMP	J:134486
Biological Process	GO:0003148	outflow tract septum morphogenesis	IMP	J:225355
Biological Process	GO:0048008	platelet-derived growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0050918	positive chemotaxis	IMP	J:174966
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:214295
Biological Process	GO:0048842	positive regulation of axon extension involved in axon guidance	IMP	J:174966
Biological Process	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	IMP	J:228701
Biological Process	GO:0010595	positive regulation of endothelial cell migration	IMP	J:214295
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	IBA	J:265628
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:197143
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:164563
Biological Process	GO:0051491	positive regulation of filopodium assembly	IMP	J:228701
Biological Process	GO:0051491	positive regulation of filopodium assembly	IBA	J:265628
Biological Process	GO:0051894	positive regulation of focal adhesion assembly	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IMP	J:197143
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	IMP	J:214295
Biological Process	GO:1902336	positive regulation of retinal ganglion cell axon guidance	IMP	J:174966
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0099173	postsynapse organization	IDA	J:106639
Biological Process	GO:0099173	postsynapse organization	IDA	J:106639
Biological Process	GO:0099173	postsynapse organization	IMP	J:106639
Biological Process	GO:1902946	protein localization to early endosome	IMP	J:197143
Biological Process	GO:0048841	regulation of axon extension involved in axon guidance	IDA	J:98330
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	IMP	J:228701
Biological Process	GO:0032489	regulation of Cdc42 protein signal transduction	ISO	J:164563
Biological Process	GO:0090259	regulation of retinal ganglion cell axon guidance	IMP	J:174966
Biological Process	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0061441	renal artery morphogenesis	IMP	J:197143
Biological Process	GO:0009611	response to wounding	IBA	J:265628
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:230295
Biological Process	GO:0061299	retina vasculature morphogenesis in camera-type eye	IMP	J:208348
Biological Process	GO:0031290	retinal ganglion cell axon guidance	IMP	J:174966
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IMP	J:225355
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IGI	J:82114
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IGI	J:91658
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IDA	J:91658
Biological Process	GO:0071526	semaphorin-plexin signaling pathway	IGI	J:82114
Biological Process	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IMP	J:142715
Biological Process	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	IMP	J:187616
Biological Process	GO:0097374	sensory neuron axon guidance	IMP	J:134486
Biological Process	GO:0002040	sprouting angiogenesis	IMP	J:208348
Biological Process	GO:0002040	sprouting angiogenesis	IBA	J:265628
Biological Process	GO:0034446	substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0006930	substrate-dependent cell migration, cell extension	ISO	J:164563
Biological Process	GO:0061549	sympathetic ganglion development	IMP	J:209482
Biological Process	GO:0061549	sympathetic ganglion development	IMP	J:187616
Biological Process	GO:0048485	sympathetic nervous system development	IMP	J:98330
Biological Process	GO:0097490	sympathetic neuron projection extension	IMP	J:187616
Biological Process	GO:0097491	sympathetic neuron projection guidance	IMP	J:187616
Biological Process	GO:1901998	toxin transport	IMP	J:197389
Biological Process	GO:0061551	trigeminal ganglion development	IMP	J:134486
Biological Process	GO:0021636	trigeminal nerve morphogenesis	IMP	J:98330
Biological Process	GO:0021637	trigeminal nerve structural organization	IMP	J:142715
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IMP	J:197143
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IMP	J:93799
Biological Process	GO:0038084	vascular endothelial growth factor signaling pathway	IEA	J:72247
Biological Process	GO:0001570	vasculogenesis	IBA	J:265628
Biological Process	GO:0038190	VEGF-activated neuropilin signaling pathway	IMP	J:197143
Biological Process	GO:0038190	VEGF-activated neuropilin signaling pathway	ISO	J:164563
Biological Process	GO:1902378	VEGF-activated neuropilin signaling pathway involved in axon guidance	IMP	J:174966
Biological Process	GO:0036486	ventral trunk neural crest cell migration	IMP	J:149474
Biological Process	GO:0021649	vestibulocochlear nerve structural organization	IMP	J:134486
Biological Process	GO:0046718	viral entry into host cell	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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