GO Annotations Graph

• Symbol: Cdc42
• Name: cell division cycle 42
• ID: MGI:106211

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0034191	apolipoprotein A-I receptor binding	ISO	J:164563
Molecular Function	GO:0003925	G protein activity	IEA	J:72245
Molecular Function	GO:0032427	GBD domain binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	ISO	J:155856
Molecular Function	GO:0005525	GTP binding	ISO	J:164563
Molecular Function	GO:0005525	GTP binding	IBA	J:265628
Molecular Function	GO:0005525	GTP binding	ISO	J:200103
Molecular Function	GO:0030742	GTP-dependent protein binding	IPI	J:113906
Molecular Function	GO:0003924	GTPase activity	ISO	J:164563
Molecular Function	GO:0003924	GTPase activity	IBA	J:265628
Molecular Function	GO:0003924	GTPase activity	IDA	J:143609
Molecular Function	GO:0003924	GTPase activity	IGI	J:143609
Molecular Function	GO:0003924	GTPase activity	IDA	J:91862
Molecular Function	GO:0003924	GTPase activity	TAS	J:65159
Molecular Function	GO:0003924	GTPase activity	ISO	J:241798
Molecular Function	GO:0003924	GTPase activity	IDA	J:80946
Molecular Function	GO:0003924	GTPase activity	ISA	J:83589
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	ISO	J:155856
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:159065
Molecular Function	GO:0005515	protein binding	IPI	J:143595
Molecular Function	GO:0005515	protein binding	IPI	J:157023
Molecular Function	GO:0005515	protein binding	IPI	J:189982
Molecular Function	GO:0005515	protein binding	IPI	J:161106
Molecular Function	GO:0005515	protein binding	IPI	J:200323
Molecular Function	GO:0005515	protein binding	IPI	J:113906
Molecular Function	GO:0005515	protein binding	IPI	J:113906
Molecular Function	GO:0005515	protein binding	IPI	J:96146
Molecular Function	GO:0005515	protein binding	IPI	J:65159
Molecular Function	GO:0005515	protein binding	IPI	J:96146
Molecular Function	GO:0005515	protein binding	IPI	J:143609
Molecular Function	GO:0005515	protein binding	IPI	J:66804
Molecular Function	GO:0005515	protein binding	IPI	J:96146
Molecular Function	GO:0005515	protein binding	IPI	J:145651
Molecular Function	GO:0005515	protein binding	IPI	J:145651
Molecular Function	GO:0005515	protein binding	IPI	J:99758
Molecular Function	GO:0005515	protein binding	IPI	J:182176
Molecular Function	GO:0005515	protein binding	IPI	J:100995
Molecular Function	GO:0005515	protein binding	IPI	J:182176
Molecular Function	GO:0005515	protein binding	IPI	J:118143
Molecular Function	GO:0005515	protein binding	IPI	J:182176
Molecular Function	GO:0005515	protein binding	IPI	J:4309
Molecular Function	GO:0005515	protein binding	IPI	J:83822
Molecular Function	GO:0019901	protein kinase binding	IPI	J:183203
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0031996	thioesterase binding	ISO	J:164563
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:164563
Cellular Component	GO:0045177	apical part of cell	IDA	J:113146
Cellular Component	GO:0031252	cell leading edge	IDA	J:279375
Cellular Component	GO:0071944	cell periphery	IDA	J:154112
Cellular Component	GO:0042995	cell projection	IDA	J:100216
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:154112
Cellular Component	GO:0005737	cytoplasm	IDA	J:97223
Cellular Component	GO:0036464	cytoplasmic ribonucleoprotein granule	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005829	cytosol	IDA	J:182176
Cellular Component	GO:0043197	dendritic spine	ISO	J:164563
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0030175	filopodium	ISO	J:164563
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:239194
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:239194
Cellular Component	GO:0000139	Golgi membrane	ISO	J:155856
Cellular Component	GO:0017119	Golgi transport complex	ISO	J:164563
Cellular Component	GO:0031256	leading edge membrane	IDA	J:185165
Cellular Component	GO:0016020	membrane	ISO	J:164563
Cellular Component	GO:0030496	midbody	ISO	J:164563
Cellular Component	GO:0072686	mitotic spindle	ISO	J:164563
Cellular Component	GO:0043209	myelin sheath	HDA	J:145263
Cellular Component	GO:0043005	neuron projection	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	ISO	J:164563
Cellular Component	GO:0045335	phagocytic vesicle	IDA	J:143718
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-3928643
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-442572
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-448947
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-5665684
Cellular Component	GO:0005886	plasma membrane	IDA	J:182176
Cellular Component	GO:0005886	plasma membrane	IDA	J:217307
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Cellular Component	GO:0030141	secretory granule	ISO	J:155856
Cellular Component	GO:0051233	spindle midzone	ISO	J:164563
Cellular Component	GO:0000322	storage vacuole	IDA	J:182176
Biological Process	GO:0030036	actin cytoskeleton organization	ISO	J:164563
Biological Process	GO:0030036	actin cytoskeleton organization	IBA	J:265628
Biological Process	GO:0090135	actin filament branching	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	ISO	J:164563
Biological Process	GO:0007015	actin filament organization	ISO	J:155856
Biological Process	GO:0034332	adherens junction organization	IMP	J:113146
Biological Process	GO:0003161	cardiac conduction system development	IGI	J:174208
Biological Process	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP	J:279375
Biological Process	GO:0032488	Cdc42 protein signal transduction	ISO	J:155856
Biological Process	GO:0032488	Cdc42 protein signal transduction	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0034329	cell junction assembly	ISO	J:164563
Biological Process	GO:0098609	cell-cell adhesion	TAS	J:113906
Biological Process	GO:0071346	cellular response to type II interferon	IDA	J:143718
Biological Process	GO:0036336	dendritic cell migration	IGI	J:185165
Biological Process	GO:0060997	dendritic spine morphogenesis	IMP	J:239194
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:279375
Biological Process	GO:0035050	embryonic heart tube development	IMP	J:279375
Biological Process	GO:0006897	endocytosis	IBA	J:265628
Biological Process	GO:0006897	endocytosis	IMP	J:216094
Biological Process	GO:0016197	endosomal transport	TAS	J:113906
Biological Process	GO:0086101	endothelin receptor signaling pathway involved in heart process	IMP	J:279375
Biological Process	GO:0045198	establishment of epithelial cell apical/basal polarity	ISO	J:164563
Biological Process	GO:0051683	establishment of Golgi localization	ISO	J:155856
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:216094
Biological Process	GO:0035088	establishment or maintenance of apical/basal cell polarity	IMP	J:113146
Biological Process	GO:0007163	establishment or maintenance of cell polarity	TAS	J:113906
Biological Process	GO:0007163	establishment or maintenance of cell polarity	IBA	J:265628
Biological Process	GO:0046847	filopodium assembly	IDA	J:80946
Biological Process	GO:0007030	Golgi organization	ISO	J:155856
Biological Process	GO:0060047	heart contraction	IGI	J:174208
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0099563	modification of synaptic structure	ISO	J:155856
Biological Process	GO:0099563	modification of synaptic structure	IBA	J:265628
Biological Process	GO:0044788	modulation by host of viral process	ISO	J:164563
Biological Process	GO:0031333	negative regulation of protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0048664	neuron fate determination	IMP	J:113146
Biological Process	GO:0038189	neuropilin signaling pathway	ISO	J:164563
Biological Process	GO:0007097	nuclear migration	IMP	J:113146
Biological Process	GO:0007097	nuclear migration	IMP	J:98926
Biological Process	GO:0051647	nucleus localization	IMP	J:113146
Biological Process	GO:0072384	organelle transport along microtubule	ISO	J:155856
Biological Process	GO:0006911	phagocytosis, engulfment	ISO	J:164563
Biological Process	GO:2000251	positive regulation of actin cytoskeleton reorganization	ISO	J:164563
Biological Process	GO:0043085	positive regulation of catalytic activity	ISO	J:155856
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0032467	positive regulation of cytokinesis	ISO	J:164563
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:155856
Biological Process	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP	J:193093
Biological Process	GO:0051491	positive regulation of filopodium assembly	IMP	J:239198
Biological Process	GO:0051491	positive regulation of filopodium assembly	ISO	J:164563
Biological Process	GO:0090316	positive regulation of intracellular protein transport	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:155856
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:150538
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IMP	J:100216
Biological Process	GO:0048549	positive regulation of pinocytosis	IMP	J:216094
Biological Process	GO:0031274	positive regulation of pseudopodium assembly	ISO	J:164563
Biological Process	GO:0051496	positive regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	ISO	J:164563
Biological Process	GO:0051835	positive regulation of synapse structural plasticity	ISO	J:155856
Biological Process	GO:0008104	protein localization	IMP	J:114581
Biological Process	GO:0006468	protein phosphorylation	IMP	J:279375
Biological Process	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	ISO	J:164563
Biological Process	GO:0051489	regulation of filopodium assembly	ISO	J:164563
Biological Process	GO:0010591	regulation of lamellipodium assembly	ISO	J:164563
Biological Process	GO:0007088	regulation of mitotic nuclear division	IMP	J:113146
Biological Process	GO:0099159	regulation of modification of postsynaptic structure	ISO	J:155856
Biological Process	GO:0099175	regulation of postsynapse organization	IDA	J:239194
Biological Process	GO:0099175	regulation of postsynapse organization	IMP	J:239194
Biological Process	GO:0043393	regulation of protein binding	IDA	J:150538
Biological Process	GO:0051492	regulation of stress fiber assembly	ISO	J:164563
Biological Process	GO:0007266	Rho protein signal transduction	TAS	J:65159
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247
Biological Process	GO:0002040	sprouting angiogenesis	ISO	J:155856