GO Annotations Graph

• Symbol: Cacna1e
• Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
• ID: MGI:106217

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005262	calcium channel activity	IEA	J:60000
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0008331	high voltage-gated calcium channel activity	IBA	J:265628
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0005216	monoatomic ion channel activity	IEA	J:72247
Molecular Function	GO:0005515	protein binding	IPI	J:114114
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:155856
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:76164
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:89452
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:66144
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:95377
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:105291
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:81788
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:66144
Molecular Function	GO:0005245	voltage-gated calcium channel activity	ISO	J:73065
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:102559
Molecular Function	GO:0005245	voltage-gated calcium channel activity	IMP	J:129620
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	ISO	J:155856
Molecular Function	GO:0022843	voltage-gated monoatomic cation channel activity	ISO	J:164563
Molecular Function	GO:0005244	voltage-gated monoatomic ion channel activity	IEA	J:60000
Cellular Component	GO:0098982	GABA-ergic synapse	ISO	J:155856
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	IBA	J:265628
Cellular Component	GO:0043204	perikaryon	ISO	J:155856
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:188270
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:188270
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:188270
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:188270
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:188270
Cellular Component	GO:0045211	postsynaptic membrane	IDA	J:188270
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:188270
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:188270
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:188270
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:188270
Cellular Component	GO:0005891	voltage-gated calcium channel complex	ISO	J:155856
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IBA	J:265628
Cellular Component	GO:0005891	voltage-gated calcium channel complex	IMP	J:144673
Cellular Component	GO:0005891	voltage-gated calcium channel complex	TAS	J:76458
Biological Process	GO:0001662	behavioral fear response	IMP	J:81788
Biological Process	GO:0048266	behavioral response to pain	IMP	J:62285
Biological Process	GO:0070509	calcium ion import	ISO	J:155856
Biological Process	GO:0098703	calcium ion import across plasma membrane	IBA	J:265628
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:102559
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:102559
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:105291
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:81788
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:105291
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:95377
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:129620
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:76164
Biological Process	GO:0070588	calcium ion transmembrane transport	IMP	J:129620
Biological Process	GO:0006816	calcium ion transport	IMP	J:89452
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:81788
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:129620
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:129620
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:102559
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:76164
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:95377
Biological Process	GO:0051649	establishment of localization in cell	IMP	J:102559
Biological Process	GO:0042596	fear response	IMP	J:62285
Biological Process	GO:0030317	flagellated sperm motility	IMP	J:76164
Biological Process	GO:0042593	glucose homeostasis	IMP	J:73855
Biological Process	GO:0042593	glucose homeostasis	IMP	J:95636
Biological Process	GO:0007626	locomotory behavior	IMP	J:62285
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:72247
Biological Process	GO:0006811	monoatomic ion transport	IEA	J:60000
Biological Process	GO:0050877	nervous system process	IMP	J:147698
Biological Process	GO:0002027	regulation of heart rate	IMP	J:105291
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:95636
Biological Process	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:95377
Biological Process	GO:0034765	regulation of monoatomic ion transmembrane transport	IEA	J:60000
Biological Process	GO:0090273	regulation of somatostatin secretion	IMP	J:129620
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	ISO	J:155856
Biological Process	GO:0048265	response to pain	IMP	J:102559
Biological Process	GO:0019233	sensory perception of pain	IMP	J:157269
Biological Process	GO:0055085	transmembrane transport	IEA	J:72247
Biological Process	GO:0019226	transmission of nerve impulse	IMP	J:144945
Biological Process	GO:0008542	visual learning	IMP	J:68192