GO Annotations Graph

• Symbol: Prpf19
• Name: pre-mRNA processing factor 19
• ID: MGI:106247

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:213904
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0061630	ubiquitin protein ligase activity	ISO	J:73065
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	IBA	J:265628
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity	ISO	J:73065
Cellular Component	GO:0071013	catalytic step 2 spliceosome	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005737	cytoplasm	ISO	J:73065
Cellular Component	GO:0005856	cytoskeleton	IEA	J:60000
Cellular Component	GO:0005662	DNA replication factor A complex	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:140901
Cellular Component	GO:0005634	nucleus	ISO	J:73065
Cellular Component	GO:0000974	Prp19 complex	ISO	J:164563
Cellular Component	GO:0000974	Prp19 complex	IBA	J:265628
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0005681	spliceosomal complex	ISO	J:110552
Cellular Component	GO:0071006	U2-type catalytic step 1 spliceosome	IBA	J:265628
Cellular Component	GO:0071007	U2-type catalytic step 2 spliceosome	ISO	J:164563
Biological Process	GO:0000077	DNA damage checkpoint signaling	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IEA	J:72247
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:0008610	lipid biosynthetic process	IDA	J:120303
Biological Process	GO:0006397	mRNA processing	IEA	J:60000
Biological Process	GO:0000398	mRNA splicing, via spliceosome	ISO	J:164563
Biological Process	GO:0000398	mRNA splicing, via spliceosome	NAS	J:320339
Biological Process	GO:0000398	mRNA splicing, via spliceosome	IBA	J:265628
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	ISO	J:155856
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome	IMP	J:140901
Biological Process	GO:0010498	proteasomal protein catabolic process	IMP	J:213904
Biological Process	GO:0010498	proteasomal protein catabolic process	ISO	J:164563
Biological Process	GO:0070534	protein K63-linked ubiquitination	ISO	J:164563
Biological Process	GO:0008104	protein localization	ISO	J:164563
Biological Process	GO:0000209	protein polyubiquitination	ISO	J:73065
Biological Process	GO:0016567	protein ubiquitination	IEA	J:72247
Biological Process	GO:0008380	RNA splicing	IEA	J:60000
Biological Process	GO:0000245	spliceosomal complex assembly	ISO	J:164563
Biological Process	GO:0000244	spliceosomal tri-snRNP complex assembly	ISO	J:164563