GO Annotations Graph

• Symbol: Lag3
• Name: lymphocyte-activation gene 3
• ID: MGI:106588

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0042289	MHC class II protein binding	IDA	J:78576
Molecular Function	GO:0042289	MHC class II protein binding	IBA	J:265628
Molecular Function	GO:0042289	MHC class II protein binding	ISO	J:40909
Molecular Function	GO:0042289	MHC class II protein binding	IDA	J:80063
Molecular Function	GO:0005515	protein binding	IPI	J:269578
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:78576
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:269578
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	IDA	J:80063
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:80063
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:32509
Cellular Component	GO:0005576	extracellular region	IDA	J:269578
Cellular Component	GO:0005576	extracellular region	IDA	J:273527
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:269578
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:78576
Biological Process	GO:0007166	cell surface receptor signaling pathway	IDA	J:80063
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0032623	interleukin-2 production	IDA	J:80063
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IDA	J:32509
Biological Process	GO:0042267	natural killer cell mediated cytotoxicity	IMP	J:32509
Biological Process	GO:0032703	negative regulation of interleukin-2 production	IDA	J:80063
Biological Process	GO:0045590	negative regulation of regulatory T cell differentiation	IMP	J:93930
Biological Process	GO:0050868	negative regulation of T cell activation	IDA	J:269578
Biological Process	GO:0050868	negative regulation of T cell activation	IDA	J:78576
Biological Process	GO:0050868	negative regulation of T cell activation	IDA	J:80063
Biological Process	GO:0002270	plasmacytoid dendritic cell activation	IMP	J:144806
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IMP	J:32509
Biological Process	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity	IDA	J:32509
Biological Process	GO:0050776	regulation of immune response	IDA	J:269578
Biological Process	GO:0042110	T cell activation	IDA	J:80063