GO Annotations Graph

• Symbol: Mthfr
• Name: methylenetetrahydrofolate reductase
• ID: MGI:106639

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0071949	FAD binding	IBA	J:265628
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:155856
Molecular Function	GO:0050660	flavin adenine dinucleotide binding	ISO	J:164563
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	ISO	J:164563
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	ISO	J:155856
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	IBA	J:265628
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity	IMP	J:93942
Molecular Function	GO:0072341	modified amino acid binding	ISO	J:164563
Molecular Function	GO:0050661	NADP binding	ISO	J:155856
Molecular Function	GO:0016491	oxidoreductase activity	IEA	J:60000
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005829	cytosol	IBA	J:265628
Cellular Component	GO:0045202	synapse	ISO	J:155856
Biological Process	GO:0070828	heterochromatin organization	ISO	J:164563
Biological Process	GO:0050667	homocysteine metabolic process	ISO	J:164563
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0009086	methionine biosynthetic process	IBA	J:265628
Biological Process	GO:0009086	methionine biosynthetic process	IMP	J:93942
Biological Process	GO:0006555	methionine metabolic process	ISO	J:164563
Biological Process	GO:0001843	neural tube closure	ISO	J:164563
Biological Process	GO:0031060	regulation of histone methylation	ISO	J:164563
Biological Process	GO:0035999	tetrahydrofolate interconversion	ISO	J:164563
Biological Process	GO:0035999	tetrahydrofolate interconversion	IBA	J:265628
Biological Process	GO:0046653	tetrahydrofolate metabolic process	ISO	J:155856