Hif1a GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Hif1a
hypoxia inducible factor 1, alpha subunit
MGI:106918

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IDA	J:93322
Molecular Function	GO:0001216	DNA-binding transcription activator activity	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IMP	J:319685
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:180719
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:93322
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:75462
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:211224
Molecular Function	GO:0070888	E-box binding	IMP	J:203819
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042826	histone deacetylase binding	IPI	J:142663
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:164563
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:176230
Molecular Function	GO:0005515	protein binding	IPI	J:161781
Molecular Function	GO:0005515	protein binding	IPI	J:110340
Molecular Function	GO:0005515	protein binding	IPI	J:203396
Molecular Function	GO:0005515	protein binding	IPI	J:203396
Molecular Function	GO:0005515	protein binding	IPI	J:210941
Molecular Function	GO:0005515	protein binding	IPI	J:161456
Molecular Function	GO:0005515	protein binding	IPI	J:247431
Molecular Function	GO:0005515	protein binding	IPI	J:35141
Molecular Function	GO:0005515	protein binding	IPI	J:122208
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	IDA	J:247431
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:319685
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI	J:41526
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:247431
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:50438
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:211224
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:164563
Molecular Function	GO:0140537	transcription regulator activator activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0000791	euchromatin	IDA	J:319685
Cellular Component	GO:0031514	motile cilium	IDA	J:74296
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0016607	nuclear speck	IDA	J:203396
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:203396
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:207460
Cellular Component	GO:0005634	nucleus	IDA	J:182491
Cellular Component	GO:0005634	nucleus	IDA	J:161456
Cellular Component	GO:0005634	nucleus	IDA	J:210293
Cellular Component	GO:0005634	nucleus	IDA	J:90918
Cellular Component	GO:0005634	nucleus	IDA	J:93322
Cellular Component	GO:0005634	nucleus	IDA	J:211224
Cellular Component	GO:0005634	nucleus	IDA	J:72709
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:73065
Biological Process	GO:0001525	angiogenesis	IMP	J:89363
Biological Process	GO:0001525	angiogenesis	IMP	J:102537
Biological Process	GO:0006915	apoptotic process	IMP	J:133149
Biological Process	GO:0006915	apoptotic process	IMP	J:133149
Biological Process	GO:0019896	axonal transport of mitochondrion	ISO	J:164563
Biological Process	GO:0001922	B-1 B cell homeostasis	IMP	J:74766
Biological Process	GO:0001568	blood vessel development	IMP	J:45554
Biological Process	GO:0048514	blood vessel morphogenesis	IMP	J:48084
Biological Process	GO:0030282	bone mineralization	IMP	J:133149
Biological Process	GO:0048593	camera-type eye morphogenesis	IGI	J:185536
Biological Process	GO:0003208	cardiac ventricle morphogenesis	IMP	J:45554
Biological Process	GO:0051216	cartilage development	IMP	J:72709
Biological Process	GO:0030154	cell differentiation	IGI	J:119854
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:155856
Biological Process	GO:0071456	cellular response to hypoxia	IBA	J:265628
Biological Process	GO:0071456	cellular response to hypoxia	IGI	J:203819
Biological Process	GO:0071456	cellular response to hypoxia	IGI	J:203819
Biological Process	GO:0071456	cellular response to hypoxia	IGI	J:203819
Biological Process	GO:0098586	cellular response to virus	ISO	J:164563
Biological Process	GO:0021987	cerebral cortex development	IMP	J:85763
Biological Process	GO:0002062	chondrocyte differentiation	IMP	J:89363
Biological Process	GO:0032963	collagen metabolic process	IMP	J:130751
Biological Process	GO:0002248	connective tissue replacement involved in inflammatory response wound healing	IMP	J:130751
Biological Process	GO:0048546	digestive tract morphogenesis	IMP	J:164015
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:117302
Biological Process	GO:0071542	dopaminergic neuron differentiation	IGI	J:117302
Biological Process	GO:0051541	elastin metabolic process	IMP	J:130751
Biological Process	GO:0035162	embryonic hemopoiesis	IMP	J:116886
Biological Process	GO:0001892	embryonic placenta development	IGI	J:119854
Biological Process	GO:0001892	embryonic placenta development	IMP	J:119854
Biological Process	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	IMP	J:82618
Biological Process	GO:0001837	epithelial to mesenchymal transition	IMP	J:130751
Biological Process	GO:0002067	glandular epithelial cell differentiation	IMP	J:82618
Biological Process	GO:0002071	glandular epithelial cell maturation	IMP	J:164015
Biological Process	GO:0002071	glandular epithelial cell maturation	IMP	J:164015
Biological Process	GO:0042593	glucose homeostasis	IMP	J:97761
Biological Process	GO:0042593	glucose homeostasis	IMP	J:121261
Biological Process	GO:0001947	heart looping	IMP	J:102537
Biological Process	GO:0042541	hemoglobin biosynthetic process	IMP	J:116886
Biological Process	GO:0097411	hypoxia-inducible factor-1alpha signaling pathway	IDA	J:12228
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	IMP	J:161456
Biological Process	GO:0035773	insulin secretion involved in cellular response to glucose stimulus	IMP	J:161456
Biological Process	GO:0060574	intestinal epithelial cell maturation	IMP	J:164015
Biological Process	GO:0060574	intestinal epithelial cell maturation	IMP	J:164015
Biological Process	GO:0060574	intestinal epithelial cell maturation	IMP	J:164015
Biological Process	GO:0001678	intracellular glucose homeostasis	ISO	J:164563
Biological Process	GO:0006879	intracellular iron ion homeostasis	IMP	J:116886
Biological Process	GO:0032364	intracellular oxygen homeostasis	ISO	J:164563
Biological Process	GO:0032364	intracellular oxygen homeostasis	IMP	J:45554
Biological Process	GO:0061072	iris morphogenesis	IGI	J:185536
Biological Process	GO:0006089	lactate metabolic process	IMP	J:97761
Biological Process	GO:0007595	lactation	IMP	J:82618
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:55063
Biological Process	GO:0097152	mesenchymal cell apoptotic process	IMP	J:55063
Biological Process	GO:0046716	muscle cell cellular homeostasis	IMP	J:97761
Biological Process	GO:0046716	muscle cell cellular homeostasis	IMP	J:97761
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:136548
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:133149
Biological Process	GO:0030502	negative regulation of bone mineralization	IMP	J:133149
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:0045926	negative regulation of growth	IMP	J:72709
Biological Process	GO:2001054	negative regulation of mesenchymal cell apoptotic process	IMP	J:55063
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:85763
Biological Process	GO:0030279	negative regulation of ossification	IMP	J:178824
Biological Process	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO	J:164563
Biological Process	GO:2000378	negative regulation of reactive oxygen species metabolic process	IMP	J:136548
Biological Process	GO:0070244	negative regulation of thymocyte apoptotic process	IMP	J:93322
Biological Process	GO:0032007	negative regulation of TOR signaling	IMP	J:164015
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045906	negative regulation of vasoconstriction	ISO	J:155856
Biological Process	GO:0001755	neural crest cell migration	IMP	J:102537
Biological Process	GO:0001755	neural crest cell migration	IMP	J:102537
Biological Process	GO:0001755	neural crest cell migration	IMP	J:102537
Biological Process	GO:0021502	neural fold elevation formation	IMP	J:55063
Biological Process	GO:0007405	neuroblast proliferation	IGI	J:117302
Biological Process	GO:0051402	neuron apoptotic process	IMP	J:85763
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:45554
Biological Process	GO:0045766	positive regulation of angiogenesis	ISO	J:164563
Biological Process	GO:0043065	positive regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0010508	positive regulation of autophagy	IMP	J:136548
Biological Process	GO:1903599	positive regulation of autophagy of mitochondrion	IMP	J:136548
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0070101	positive regulation of chemokine-mediated signaling pathway	ISO	J:164563
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:155856
Biological Process	GO:0010634	positive regulation of epithelial cell migration	IMP	J:130751
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	IMP	J:116886
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0045722	positive regulation of gluconeogenesis	ISO	J:155856
Biological Process	GO:0046886	positive regulation of hormone biosynthetic process	ISO	J:164563
Biological Process	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	J:161456
Biological Process	GO:0016239	positive regulation of macroautophagy	IMP	J:148996
Biological Process	GO:1902895	positive regulation of miRNA transcription	IMP	J:319685
Biological Process	GO:1902895	positive regulation of miRNA transcription	ISO	J:164563
Biological Process	GO:0002052	positive regulation of neuroblast proliferation	IGI	J:117302
Biological Process	GO:2000273	positive regulation of signaling receptor activity	ISO	J:164563
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	ISO	J:155856
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:203819
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:211224
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:119731
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:41526
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:73065
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:180719
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:35141
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:41526
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98265
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:98265
Biological Process	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	ISO	J:164563
Biological Process	GO:0010575	positive regulation of vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	IMP	J:72709
Biological Process	GO:0035470	positive regulation of vascular wound healing	ISO	J:155856
Biological Process	GO:1903715	regulation of aerobic respiration	IMP	J:136548
Biological Process	GO:0050790	regulation of catalytic activity	IMP	J:97761
Biological Process	GO:0042127	regulation of cell population proliferation	IMP	J:121261
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:93322
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:75462
Biological Process	GO:0010468	regulation of gene expression	IMP	J:136548
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0006110	regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0006110	regulation of glycolytic process	IGI	J:121261
Biological Process	GO:2000434	regulation of protein neddylation	ISO	J:164563
Biological Process	GO:0070243	regulation of thymocyte apoptotic process	IGI	J:93322
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO	J:155856
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	ISO	J:164563
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IMP	J:84384
Biological Process	GO:0032909	regulation of transforming growth factor beta2 production	ISO	J:164563
Biological Process	GO:0060992	response to fungicide	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:155856
Biological Process	GO:0001666	response to hypoxia	ISO	J:164563
Biological Process	GO:0001666	response to hypoxia	IMP	J:319685
Biological Process	GO:0001666	response to hypoxia	IMP	J:48084
Biological Process	GO:0001666	response to hypoxia	IMP	J:53389
Biological Process	GO:0001666	response to hypoxia	ISO	J:75462
Biological Process	GO:0001666	response to hypoxia	IGI	J:121261
Biological Process	GO:0001666	response to hypoxia	IDA	J:35141
Biological Process	GO:0001666	response to hypoxia	IMP	J:73981
Biological Process	GO:0001666	response to hypoxia	IDA	J:74294
Biological Process	GO:0001666	response to hypoxia	IMP	J:148996
Biological Process	GO:0014850	response to muscle activity	IMP	J:97761
Biological Process	GO:0000302	response to reactive oxygen species	ISO	J:164563
Biological Process	GO:0061298	retina vasculature development in camera-type eye	IMP	J:171540
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0031929	TOR signaling	IMP	J:164015
Biological Process	GO:0031929	TOR signaling	IMP	J:164015
Biological Process	GO:0010573	vascular endothelial growth factor production	ISO	J:164563
Biological Process	GO:0001944	vasculature development	IGI	J:139006
Biological Process	GO:0008542	visual learning	IMP	J:85763

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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